Preface. Acknowledgments. Evaluation of Mitochondrial Function in Living Cells. 1. Flow Cytometric Analysis of Mitochondrial Function; H. Rottenberg. 2. Confocal Microscopy of Mitochondrial Function in Living Cells; J.L. Lemasters, et al. 3. Primary Disorders of Mitochondrial DNA and the Pathophysiology of mtDNA-related Disorders; E.A. Schon, S. DiMauro. 4. Transmission and Segregation of Mammalian Mitochondrial DNA; E.A. Shoubridge. 5. Cardiac Reperfusion Injury: Aging, Lipid Peroxidation, and Mitochondrial Function; L.I. Szweda, et al. Mitochondrial Ion Homeostatis and Necrotic Cell Death. 6. Ca2+-Induced Transition in Mitochondria: A Cellular Catastrophe? R.A. Haworth, D.R. Hunter. 7. Physiology of the Permeability Transition Pore; M. Zoratti, F. Tombola. 8. Control of Mitochondrial Metabolism by Calcium-dependent Hormones; P. Burnett, et al. 9. The Permeability Transition Pore in Myocardial Ischemia and Reperfusion; A.P. Halestrap, et al. 10. Mitochondrial Calcium Dysregulation during Hypoxic Injury to Cardiac Myocytes; E.J. Griffiths. Apoptosis. 11. Mitochondrial Implication in Cell Death; P.X. Petit. 12. Role of Mitochondria in Apoptosis Induced by Tumor Necrosis Factor-alpha; C.A. Bradham, et al. 13. The ATP Switch in Apoptosis; D.J. McConkey. Mitochondria, Free Radicals and Disease. 14. Reactive Oxygen Generation by Mitochondria; A.J. Kowaltowski, A.E. Vercesi. 15. The Role of the Permeability Transition in Glutamate-mediated Neuronal Injury; I.J. Reynolds, T.G. Hastings. 16. Mitochondrial Dysfunction in the Pathogenesis of Acute Neural Cell Death; G. Fiskum. 17. Varied Responses of CNS Mitochondria to Calcium; N. Brustovetsky, J.M. Dubinsky. 18. Mitochondrial Dysfunction in Oxidative Stress, Excitotoxicity, and Apoptosis; A.-L. Nieminen, et al. 19. Mitochondria in Alcoholic Liver Disease; J.C. Fernández-Checa, et al. 20. Mitochondrial Depolarization and Permeability Changes after Acute Alcohol; H. Higuchi, H. Ishii. 21. Mitochondrial Dysfunction in Chronic Fatigue Syndrome; B. Chazotte. Chemical Toxicity. 22. Bile Acid Toxicity; G.J. Gores. 23. Reye's Related Chemical Toxicity; L.C. Trost, J.J. Lemasters. 24. Purinergic Receptor-mediated Cytotoxicity; J.F. Nagelkerke, J.P. Zoetewey. 25. Doxorubicin-induced Mitochondrial Cardiomyopathy; K.B. Wallace. 26. Drug-induced Microvesicular Steatosis and Steatohepatitis; D. Pessayre, et al.