Boeken van Frank Bretz

Jiawei Wei Leslie Meng Frank Bretz Feng Chen Jun Wang
Estimands in Clinical Trials
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This book provides a comprehensive, up-to-date, and practical introduction to the estimand framework and its application in clinical trials. Meer
KyungMann Kim Frank Bretz Ying Kuen K. Cheung Lisa V. Hampson
Handbook of Statistical Methods for Randomized Controlled Trials
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Statistical concepts provide scientific framework in experimental studies, including randomized controlled trials. In order to design, monitor, analyze and draw conclusions scientifically from such clinical trials, clinical investigators and statisticians should have a firm grasp of the requisite statistical concepts. Meer
Alan Genz Frank Bretz
Computation of Multivariate Normal and t Probabilities
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This book describes recently developed methods for accurate and efficient computation of the required probability values for problems with two or more variables. Meer
Frank Bretz Torsten Hothorn Peter Westfall
Multiple Comparisons Using R
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Adopting a unifying theme based on maximum statistics, Multiple Comparisons Using R describes the common underlying theory of multiple comparison procedures through numerous examples. Meer
Alex Dmitrienko Ajit C. Tamhane Shein-Chung Chow Frank Bretz
Multiple Testing Problems in Pharmaceutical Statistics
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Useful Statistical Approaches for Addressing Multiplicity Issues
Includes practical examples from recent trials


Bringing together leading statisticians, scientists, and clinicians from the pharmaceutical industry, academia, and regulatory agencies, Multiple Testing Problems in Pharmaceutical Statistics explores the rapidly growing area of multiple comparison research with an emphasis on pharmaceutical applications. Meer

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