Edward Kerns
- Auteur
Boeken van Edward Kerns
Li East Lyme, Ct
Li Di
Edward Institutes Of Health, Bethesda,
Edward Kerns
Edward Kerns
Drug-Like Properties
Of the thousands of novel compounds that a drug discovery project team invents and that bind to the therapeutic target, only a fraction have sufficient ADME (absorption, distribution, metabolism, elimination) properties, and acceptable toxicology properties, to become a drug product that will successfully complete human Phase I clinical trials.
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Ronald Borchardt
Edward Kerns
Christopher Lipinski
Dhrien Thakker
Binghe Wang
Pharmaceutical Profiling in Drug Discovery for Lead Selection
At a time when pharmaceutical companies have limited resources to develop newer and better drugs, they must continually evaluate the effectiveness and efficiency of their research and development process.
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Ronald Borchardt
Edward Kerns
Michael Hageman
Dhrien Thakker
James Stevens
Optimizing the "Drug-Like" Properties of Leads in Drug Discovery
Drug discovery and development is a very complex, costly, and ti- consuming process. Because of the uncertainties associated with predicting the pharmacological effects and the toxicity characteristics of new chemical entities in man, their clinical development is quite prone to failure.
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