Sigma Receptors

Dedication.<br>Contributors.<br>Series Preface.<br>Preface.<br>Historical Perspective: Evolution of the Concept of Sigma Receptor.<br>Sigma Receptors in the Central Nervous System and the Periphery.<br>Structure-Activity Relationships and Evolution of Sigma Receptor Ligands (1976-present).<br>Multiple Sigma Binding Sites in the Brain.<br>Interaction of Sigma Receptors with Signal Transduction Pathways and Effects on Second Messengers.<br>Recent Evidence for Endogenous Substance(s) for Sigma Receptors.<br>Potential Therapeutic Application of Sigma Receptor Antagonists.<br>Role of Sigma Receptors in Brain Mechanisms of Movement.<br>Imaging Sigma Receptors and Cerebral Responses to Sigma Drugs.<br>Effects of Cytochrome P-450 Ligands on the Binding of [3H]dextromethorphan and Sigma Ligands to Guinea Pig Brain.<br>Putative Interactions Between Sigma Binding Sites and Neuropeptide Y.<br>Role of Sigma Binding Sites in the Modulation of Endocrine and Immune Functions.<br>The Sigma Receptor: Concluding Remarks/Future Vistas.<br>Index.