Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors

Gebonden Engels 2013 9780123945877
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In this thematic volume of Progress in Molecular Biology and Translational Science, researchers reflect on recent developments and research surrounding G protein-coupled receptors. The chapters cover a large breadth of research, including GPCR role in stem cell function and pharmacology.

Authors explore in-depth research techniques and applications of GPCR usage, covering theory, laboratory approaches, and unique qualities that make GPCRs a crucial tool in microbiological and cancer research.

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Inhoudsopgave

  1. Approaches for Probing Allosteric Interactions at 7 Transmembrane Spanning Receptors
  2. Michael T. Klein, Paige N. Vinson and Colleen M. Niswender
  3. Pharmacology of Metabotropic Glutamate Receptor Allosteric Modulators: Structural Basis and Therapeutic Potential for CNS Disorders
  4. Karen J. Gregory, Meredith J. Noetzel and Colleen M. Niswender
  5. Mining the Potential of Label-Free Biosensors for Seven-Transmembrane Receptor Drug Discovery
  6. Magalie Rochville, Julio Martin, Jeffrey Clifford Jerman & Evi Kostenis
  7. G Protein-Coupled Receptors in Cancer : Biochemical Interactions and Drug Design
  8. Yves Audigier, François-Xavier Picault, Carline Chaves-Almagro and Bernard Masri
  9. GPCRs in Stem Cell Function
  10. Van A. Doze and Dianne M. Perez
  11. Application of Receptor Theory to Allosteric Modulation of Receptors
  12. David A. Hall
  13. What Ligand-Gated Ion Channels Can Tell Us about the Allosteric Regulation of G protein-Coupled Receptors
  14. Frederick J. Ehlert
  15. Modelling Cooperativity Effects in Dimeric G Protein-Coupled Receptors
  16. Jesús Giraldo
  17. Chemokine Receptor Oligomerization and Allostery
  18. Bryan Stephens and Tracy M. Handel
  19. Fine-Tuning of GPCR Signals by Intracellular G Protein Modulators

    Peishen Zhao, Wendy Cladman, Hubert HM Van Tol and Peter Chidiac

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          Oligomerization and Allosteric Modulation in G-Protein Coupled Receptors