Epigenetic Technological Applications

Preface1. Introduction of the Epigenetic Technologies2. Technologies for the Measurement and Mapping of Genomic 5-methylcytosine and 5-hydroxymethylcytosine3. Technologies to Map DNA 5hC and 5fC and 5caC4. Application of Mass Spectrometry in Translational Epigenetics5. Techniques Analyzing Chromatin Modifications at Specific Single Loci6. Comprehensive Analysis of Mammalian Linker-histone Variants and Their Mutants7. Crystallography-based Mechanistic Insights into Epigenetic Regulation8. Chemical and Genetic Approaches to Study Histone Modifications9. Peptide Microarrays for Profiling of Epigenetic Targets10. Current Methods for Methylome Profiling11. Bioinformatics and Biostatistics for Mining Epigenetic Disease Markers and Targets12. Computational Modeling to Elucidate Molecular Mechanisms of Epigenetic Memory13. DNA Methyltransferase Inhibitors for Cancer Therapy14. Histone Acetyltransferases: Enzymes, Assays, and Inhibitors15. In Vitro Histone Deacetylase Activity Screening: Making a Case for Better Assays 16. Enzymatic Assays of Histone Methyltransferase Enzymes17. Histone Methyltransferase Inhibitors for Cancer Therapy18. Discovery of Histone Demethylase Inhibitors19. Fluorescent Technologies in Studying Dynamics of Histone Modification20. Animal Model Study of Epigenetic Inhibitors