Dyneins

<p>I. Structure and Mechanics of Dynein Motors<br>1. Electron microscopy of isolated dynein complexes and the power stroke mechanism<br>2. Mechanism and regulation of dynein motors<br>3. Structural analysis of dynein intermediate and light chains<br>4. Biochemical purification of axonemal and cytoplasmic dyneins<br>5. Single molecule dynein motor mechanics in vitro<br>6. Biophysical properties of dynein in vivo<br>7. Mechanics of bidirectional cargo transport<br>8. Chemical probes for dynein<br>9. Computational modeling of dynein activity and the generation of flagellar beating waveforms</p> <p>II. Dynein Dysfunction and Disease<br>10. Impacts of virus-mediated manipulation of host dynein<br>11. Use of mouse genetics to probe cytoplasmic dynein function<br>12. Cytoplasmic dynein and its regulators in neocortical development and disease<br>13. Cytoplasmic dynein dysfunction and neurodegenerative disease<br>14. Dynein dysfunction as a cause of primary ciliary dyskinesia and other ciliopathies<br>15. Severe skeletal abnormalities caused by defects in retrograde intraflagellar transport dyneins<br>16. Ciliary dynein dysfunction as a consequence of chronic alcohol exposure<br>17. Dynein-based motility of pathogenic protozoa<br>18. Dynein axonemal light chain 4: involvement in congenital mirror movement disorder<br>19. Does dynein influence the non-Mendelian inheritance of chromosome 17 homologues in male mice?</p>