Prion Protein

<p>1. Functions of the Prion Protein<br>Théo Z. Hirsch, Séverine Martin-Lannerée and Sophie Mouillet-Richard<br>2. Copper- and Zinc-Promoted Interdomain Structure in the Prion Protein: A Mechanism for Autoinhibition of the Neurotoxic N-Terminus<br>Eric G.B. Evans and Glenn L. Millhauser<br>3. Cell Biology of Prion Protein<br>Daniela Sarnataro, Anna Pepe and Chiara Zurzolo<br>4. Understanding the Effect of Disease-Related Mutations on Human Prion Protein Structure: Insights From NMR Spectroscopy<br>Ivana Biljan, Gregor Ilc and Janez Plavec<br>5. Structural Modeling of Human Prion Protein’s Point Mutations<br>Giulia Rossetti and Paolo Carloni<br>6. Prion Protein and Genetic Susceptibility to Diseases Caused by Its Misfolding<br>George A. Carlson<br>7. The Prion Concept and Synthetic Prions<br>Giuseppe Legname and Fabio Moda<br>8. Gene Targeted Transgenic Mouse Models in Prion Research<br>Abigail B. Diack, James D. Alibhai and Jean C. Manson<br>9. Transmission and Replication of Prions<br>A. Marín-Moreno, N. Fernández-Borges, J.C. Espinosa, O. Andréoletti and J.M. Torres<br>10. Immunology of Prion Protein and Prions<br>Neil A. Mabbott<br>11. Phenotypical Variability in Bovine Spongiform Encephalopathy: Epidemiology, Pathogenesis, and Diagnosis of Classical and Atypical Forms<br>Cristiano Corona, Elena V. Costassa, Barbara Iulini, Elena Bozzetta, Maria Mazza, Rosanna Desiato, Giuseppe Ru and Cristina Casalone<br>12. Scrapie, CWD, and Transmissible Spongiform Encephalopathy<br>Candace K. Mathiason<br>13. Infectious and Sporadic Prion Diseases<br>Richard Knight<br>14. Neuropathology of Human Prion Diseases<br>Diane L. Ritchie and James W. Ironside<br>15. The Structure of the Infectious Prion Protein and Its Propagation<br>Jesús R. Requena and Holger Wille<br>16. Protein Misfolding Cyclic Amplification of Infectious Prions<br>Fabio Moda<br>17. Amplified Detection of Prions and Other Amyloids by RT-QuIC in Diagnostics and the Evaluation of Therapeutics and Disinfectants<br>Byron Caughey, Christina D. Orru, Bradley R. Groveman, Andrew G. Hughson, Matteo Manca, Lynne D. Raymond, Gregory J. Raymond, Brent Race, Eri Saijo and Allison Kraus<br>18. Biochemical Characterization of Prions<br>Michele Fiorini, Matilde Bongianni, Salvatore Monaco and Gianluigi Zanusso<br>19. Omics of Prion Diseases<br>Silvia Vanni<br>20. Therapeutic Approaches to Prion Diseases<br>Annachiara Gandini and Maria L. Bolognesi<br>21. Biosafety of Prions<br>Edoardo Bistaffa, Martina Rossi, Chiara M.G. De Luca and Fabio Moda</p>