Platform Technologies in Drug Discovery and Validation

<p>1. DNA-Encoded Library Technology: A Brief Guide to Its Evolution and Impact on Drug Discovery<br>Robert A. Goodnow Jr. and Christopher P. Davie<br>2. The Chemistry of Oligonucleotide Delivery<br>David B. Rozema<br>3. CRISPR–Cas9 for Drug Discovery in Oncology<br>Sylvie M. Guichard<br>4. Recent Advances of Microfluidics Technologies in the Field of Medicinal Chemistry<br>László Ürge, Jesus Alcazar, Lena Huck and György Dormán<br>5. High-Throughput Screening<br>Mary Jo Wildey, Anders Haunso, Matthew Tudor, Maria Webb and Jonathan H. Connick<br>6. Kinase-Centric Computational Drug Development<br>Albert J. Kooistra and Andrea Volkamer<br>7. Free Energy Calculation Guided Virtual Screening of Synthetically Feasible Ligand R-Group and Scaffold Modifications: An Emerging Paradigm for Lead Optimization<br>Robert Abel and Sathesh Bhat<br>8. Phenotypic Screening<br>Alleyn T. Plowright and Lauren Drowley<br>9. Targeted Protein Degradation<br>Nello Mainolfi and Tim Rasmusson<br>10. Chemical Biology in Drug Discovery<br>M. Paola Castaldi, Andrea Zuhl, Piero Ricchiuto and J. Adam Hendricks<br>11. Fragment-Based Lead Discovery<br>Ben J. Davis and Stephen D. Roughley<br>12. Antibody-Drug Conjugates<br>Amit Kumar, Jason White, R. James Christie, Nazzareno Dimasi and Changshou Gao<br>13. Antibody-Recruiting Small Molecules: Synthetic Constructs as Immunotherapeutics<br>Patrick J. McEnaney, Christopher G. Parker and Andrew X. Zhang<br>14. A Decade of Deuteration in Medicinal Chemistry<br>Julie F. Liu, Scott L. Harbeson, Christopher L. Brummel, Roger Tung, Robert Silverman and Dario Doller<br>15. From Natural Peptides to Market<br>Claudio D. Schteingart and Jolene L. Lau</p>