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Advances in Structural Biology

Applications in Protein Structure, Function, and Disease

Paperback Engels 2026 9780443449888
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Advances in Structural Biology: Applications in Protein Structure, Function, and Disease offers a comprehensive, practical resource that bridges the latest experimental and computational approaches in structural biology. Backed by real-world case studies, it demonstrates how these technologies can be utilized to serve a range of biological needs. The content spans foundational principles of protein structure and bioinformatics tools, cutting-edge methodologies such as cryogenic electron microscopy, and the transformative role of artificial intelligence (AI) and big data analytics in structural biology. It also considers applications including drug discovery, vaccine development, antiviral therapy, personalized medicine, and the structural basis of aging and neurodegenerative diseases. This book also explores systems integration approaches, combining structural and omics data to advance immunotherapy and cancer treatment, concluding with a look toward future trends in the field.

Advances in Structural Biology: Applications in Protein Structure, Function, and Disease provides a detailed investigation into the latest developments in structural and computational biology, sharing insights into integrative methodologies that combine both traditional and emerging technologies. This resource is invaluable for advanced students, researchers, and professionals aiming to harness structural biology for innovative solutions in precision medicine and translational research.

Specificaties

ISBN13:9780443449888
Taal:Engels
Bindwijze:Paperback
Aantal pagina's:702

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Inhoudsopgave

Section I – Foundations: computational and conceptual1. Unraveling protein function with structural biology approaches
2. Bioinformatics tools for protein modeling in neurodegenerative diseases
3. Bioinformatics tools for protein modeling in cancer
4. Unraveling protein folding and structural dynamics

Section II – Methodologies: experimental and integrative techniques
5. Cryo-electron microscopy in membrane protein structural biology
6. Computational and artificial intelligence methodologies for big data analytics in structural biology
7. Big data enabled discovery in bioinformatics and structural biology
8. AI and machine learning in structural biology
9. Integrating structural and omics data for drug discovery

Section III – Applications
10. Applications of structural biology in drug discovery
11. Structural biology approaches in vaccine development
12. Structural biology in antiviral drug design
13. Structural bioinformatics in personalized medicine
14. Structural biology in understanding bacterial resistance
15. Structural biology approaches in neurodegeneration and aging
16. Structural biology of protein misfolding and aggregation: from disease to therapeutic innovations
17. Integrated structural approaches in immunotherapy

Section IV – Translational biology
18. Structural and systems biology in cancer therapy
19. Protein structural biology in precision medicine and clinical translation
20. Future trends in structural biology

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          Advances in Structural Biology