Fluoropyrimidines in Cancer Therapy

1 Relative Role of 5-Fluorouracil Activation and Inactivation Pathways on its Cytotoxic Effects: Preclinical and Clinical Modulation.- 2 Dihydropyrimidine Dehydrogenase and Treatment by Fluoropyrimidines: Past and Future Directions.- 3 Biochemical Bases of the 5-Fluorouracil—Folinic Acid Interaction and of its Limitations: A Retrospective Analysis.- 4 Molecular Mechanisms Regulating the Expression of Thymidylate Synthase.- 5 Regulation of Thymidylate Synthase Gene Expression and Drug Response: Posttranscriptional Regulation and Cell Population Density.- 6 Death Receptor Signaling in the Mechanism of 5-Fluorouracil Action.- 7 Circadian Rhythms in 5-Fluorouracil Pharmacology and Therapeutic Applications.- 8 Relevance of Scheduling to the Efficacy of 5-Fluorouracil Alone and in Combination with Other Agents.- 9 Noninvasive Studies of Fluoropyrimidines.- 10 Comparative Antitumor Activity of 5-Fluorouracil (5-FU) Prodrugs in Preclinical Model Systems: Role of Leucovorin and Dihydropyrimidine Dehydrogenase Inhibitors.- 11 Bimonthly 48-h Leucovorin and 5-Fluorouracil-Based Regimens in Advanced Colorectal Cancer.- 12 Review on the Combination of Systemic and Locoregional Treatment for Colorectal Liver Metastases.- 13 Fluoropyrimidines in Advanced Colorectal Cancer: A Review of Six Consecutive Meta-Analyses.- 14 The Mayo/NCCTG Experience with 5-Fluorouracil and Leucovorin in Adjuvant Advanced Colorectal Cancer.- 15 Fluoropyrimidines for the Adjuvant Treatment of Colorectal Cancer: The NSABP Experience.- 16 Clinical Trials of UFT Leucovorin in Gastrointestinal Malignancies.- 17 The Development of Oral UFT with and without Leucovorin.- 18 UFT in Elderly Patients with Colorectal Cancer.- 19 Clinical Trials of the Eniluracil/5-Fluorouracil Combination.- 20 Discovery andPreclinical Pharmacology of Capecitabine.- 21 Capecitabine, A Tumor-Targeting Oral Fluoropyrimidine: Molecular Rationale and Clinical Validation.- 22 Capecitabine: A Rationally Developed Anticancer Drug.- 23 Preclinical and Clinical Practice of S-1 in Japan.- 24 Preclinical and Clinical Practice of Low-Dose FP Therapy in Japan: Japanese Use of Low-Dose FP Therapy.