Oncogene-Directed Therapies

I. Basic Concepts in Oncogene Research.- 1 Genetic Basis of Cancer Progression.- 2 The Molecular Basis of Chromosomal Instability in Human Cancer Cells.- 3 Signal Transduction Networks: Ras as a Paradigm.- 4 Oncogenic Receptor Tyrosine Kinases.- 5 Ras-Mediated Deregulation of Gene Expression and Contribution to Oncogenesis.- 6 The Interplay Between Tumor Suppressor Genes and Oncogenes in Tumorigenesis.- 7 Genetic Basis of Altered Responsiveness of Cancer Cells to Their Microenvironment.- II. The Functional Impact of Oncogene Expression on Cancer Cellstherapeutic Implications.- 8 Deregulation of Cell Cycle Progression by Oncogenic Transformation.- 9 Oncogenes as Regulators of Cell Survival: The Role of Oncogenes and Tumor Suppressor Genes in the Induction of Resistance to Anoikis and Hypoxia.- 10 Oncogenes and Tumor Angiogenesis.- 11 Oncogenes as Therapeutic Targets to Prevent Metastasis.- 12 The Impact of Oncogenes on Tumor Maintenance.- 13 Primary and Secondary Events in Oncogene-Driven Tumor Development: Lessons from Transgenic Model Systems.- III. Oncogenes as Targets for Anticancer Therapy In Vivo.- 14 Targeting Oncogenes in Hematopoietic Malignancies.- 15 Clinical Evaluation of Agents Targeting Epidermal Growth Factor Receptor (EGFR) in Cancer.- 16 Inhibition of the HER-2/neu Oncogene: A Translational Research Model for the Development of Future Targeted Therapies.- 17 Farnesyltransferase Inhibitors as Anticancer Agents.- 18 Targeting Oncogenic Signaling Pathways in Human Astrocytomas.- 19 Targeting Oncogenes in Pediatric Malignancies.- 20 Inhibiting Signal Transduction as an Approach to Radiosensitizing Tumor Cells.- 21 Oncogenes as Targets for Cancer Vaccines.- 22 Bcl-2 Antisense Oligonucleotides Therapy for Cancer: Targeting the Mitochondria.