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Computational Neuroscience

Gebonden Engels 2026 9781071654392
€ 240,99
Levertijd ± 9 werkdagen
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Samenvatting

This detailed volume explores practical and reproducible computational techniques and pipelines that span the translational neurosciences continuum. The first section of the book focuses on experimental platforms that generate high-dimensional biological data and the computational methodologies required to transform raw signals into mechanistic insights, while the second half transitions from bench to bedside, illustrating how computational methodologies reshape diagnosis, prognosis, and mechanistic inference across the whole pathophysiological spectrum of the nervous system, from normal brain function to neurological diseases. Written for the highly successful Methods in Molecular Biology series, each chapter provides step-by-step workflows, code snippets, tool recommendations, and the practical guidance needed for positive results.

Authoritative and up-to-date, Computational Neuroscience serves as both a reference and a catalyst: a reference for reproducible pipelines across diverse subfields, and a catalyst for interdisciplinary collaboration.

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Inhoudsopgave

Data Processing and Machine Learning Methods to Analyze MALDI-TOF MS Data.- An R-Based Workflow for Analysis of Data Independent Acquisition (DIA) Neuroproteomics Data.- Entropy and Fractal Dimensions Application in MALDI-TOF MS Data to Train Classification Models.- An Introduction to Structural Phylogenetics for Biomedical Sciences.- Segmentation-Free Multi-Fractal and Radiomics Response Profiling of Live Unstained Confluent Microglia In Vitro Using Phase-Contrast Microscopy Images.- Computational Pipeline to Infer Micro-, Meso-, and Macro-Scale Brain-State Transitions.- Computational Spatial Modeling of Extrachromosomal DNA to Decipher Cancer Evolution.- Network Analysis Pipeline for Neuronal 2D and 3D Organoid Multielectrode Recordings.- A Computational Protocol for Whole Brain Histology Imaging.- Computational Pipeline in Neuroradiomics.- Computational Pipeline in Clinical Connectomics.- A Multiscale Methodology for Mapping Human Neuroanatomy.- Federated Learning Pipeline for Whole-Slide Image Classification in Digital Neuropathology.- Using Large Language Model Embeddings to Analyze Neural Activity During Language Processing.- Leveraging Identity-by-Descent for Disease Gene Discovery.

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          Computational Neuroscience