Kathleen H. Goss,
Michael Kahn
Targeting the Wnt Pathway in Cancer
Paperback Engels 2014 9781489981646Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
Inappropriate activation of the Wnt signaling pathway is observed in many human cancers and is sufficient to drive tumor initiation and progression in numerous contexts. Multiple mechanisms, such as overexpression of Wnt ligands, inactivation of the APC and Axin tumor suppressors, and mutation of -catenin, are responsible for pathway activation in tumor cells. The development of potent Wnt pathway antagonists for therapeutic use has been a major effort for investigators in both academia and industry in recent years. This book will provide an overview of the Wnt pathway as a therapeutic target for cancer, and discuss the preclinical development of inhibitors specifically directed to upstream and downstream components of the pathway.
Specificaties
ISBN13:9781489981646
Taal:Engels
Bindwijze:paperback
Uitgever:Springer New York
Lezersrecensies
Wees de eerste die een lezersrecensie schrijft!
Inhoudsopgave
Chapter 1. An Introduction to Wnt Signaling
Paul Polakis
Chapter 2. Regulation of Wnt Secretion and Distribution
Xiaofang Tang Xiaolan Fan and Xinhua Lin
Chapter 3. Wnt Signaling in Stem Cells
Philipp C. Manegold, Jia-Ling and Teo Michael Kahn
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Chapter 4. Crosstalk of the Wnt Signaling Pathway
Michael Thompson, Kari Nejak-Bowen, Satdarshan P. S. Monga
Chapter 5. Dysregulation of the WNT Pathway in Solid Tumors
Jenifer R. Prosperi, Hue H. Luu and Kathleen H. Goss
Chapter 6. WNT/b-catenin Signaling in Leukemia
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Paul Polakis
Chapter 2. Regulation of Wnt Secretion and Distribution
Xiaofang Tang Xiaolan Fan and Xinhua Lin
Chapter 3. Wnt Signaling in Stem Cells
Philipp C. Manegold, Jia-Ling and Teo Michael Kahn
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Chapter 4. Crosstalk of the Wnt Signaling Pathway
Michael Thompson, Kari Nejak-Bowen, Satdarshan P. S. Monga
Chapter 5. Dysregulation of the WNT Pathway in Solid Tumors
Jenifer R. Prosperi, Hue H. Luu and Kathleen H. Goss
Chapter 6. WNT/b-catenin Signaling in Leukemia
Markus Müschen
Chapter 7. Use of Genetically-engineered Mouse Models in Identification and Validation of Therapeutic Targets for Colon Cancer
Masahiro Aoki and Makoto Mark Taketo
Chapter 8. Targeting Wnt Signalling in Cancer
Aliaksei Holik and Alan R. Clarke
Cardiff School of Biosciences, Cardiff University,Cardiff, UK
Chapter 9. Inhibiting the Wnt Signaling Pathway with Small Molecules
Ho-Jin Lee, Xinxin Zhang, and Jie J. Zheng
Chapter 10. Targeting of Wnt Signaling Inside the Nucleus
Miki Shitashige and Tesshi Yamada
Rubrieken
- advisering
- algemeen management
- coaching en trainen
- communicatie en media
- economie
- financieel management
- inkoop en logistiek
- internet en social media
- it-management / ict
- juridisch
- leiderschap
- marketing
- mens en maatschappij
- non-profit
- ondernemen
- organisatiekunde
- personal finance
- personeelsmanagement
- persoonlijke effectiviteit
- projectmanagement
- psychologie
- reclame en verkoop
- strategisch management
- verandermanagement
- werk en loopbaan