Fc Receptors
Gebonden Engels 2014 2014e druk 9783319079103Samenvatting
This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after FcµR and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of FcεRI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcγRIIB and FcαRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
Specificaties
Lezersrecensies
Inhoudsopgave
Hiromi Kubagawa, Yoshiki Kubagawa, Dewitt Jones, Tahseen H. Nasti, Mark Walter, and Kazuhito Honjo
The Old but New IgM Fc Receptor (FcμR)
F.J. Li, W.J. Won, E.J. Becker Jr., J.L. Easlick, E. Tabengwa, R. Li, M. Shakhmatov, P.D. Burrows, and R.S. Davis
Emerging Roles for FCRL Family Members in Lymphocyte Biology and Disease
Leo C. James
Intracellular antibody immunity and the cytosolic Fc receptor TRIM21
Part II: FcR signaling
Anna Niarakis, Yacine Bounab, Luca Grieco, Roman Roncagalli, Jérôme Garin, Bernard Malissen, Marc Daëron, Denis Thieffry
Computational modeling of the main signaling pathways involved in mast cell activation
Tarik Attout, Andres Floto and Pierre Launay
Calcium channels in FcR signaling
Marcel Kuhny, Carolin N. Zorn, and Michael Huber
Regulation of FcεRI signaling by lipid phosphatases
Part III: FcR biology
Marc Daëron
Fc Receptors as Adaptive Immunoreceptors
Jerrard M Hayes, Eoin FJ Cosgrave, Weston B Struwe, Mark Wormald, Gavin P. Davey, Roy Jefferis, Pauline M Rudd
Glycosylation and Fc Receptors
Birgitta Heyman
Antibodies as natural adjuvants
Sanae Ben Mkaddem, Ivy Christou, Elisabetta Rossato, Laureline Berthelot, Agnès Lehuen and Renato C. Monteiro
IgA, IgA receptors and their anti-inflammatory properties
Stylianos Bournazos, David J. DiLillo and Jeffrey V. Ravetch
Humanized mice to study FcγR function
Dilip K. Challa, Ramraj Velmurugan, Raimund J. Ober and E. Sally Ward
FcRn: from molecular interactions to regulation of IgG pharmacokinetics and functions.
Part IV: FcRs and disease
Xinrui Li, Andrew W Gibson and Robert P Kimberly
Human FcR polymorphism and disease.
Hanane el Bannoudi, Andreea Ioan-Facsinay and René E. M. Toes
Bridging auto-antibodies and arthritis; the role of Fc Receptors
P. Mark Hogarth, Jessica C. Anania, Bruce D. Wines
The FcγR of humans and non-human primates and their interaction with IgG: Implications for induction of inflammation, resistance to infection and the use of therapeutic monoclonal antibodies
Part V: FcRs and therapeutic antibodies
Ann L White, Stephen A Beers and Mark S. Cragg
FcgRIIB as a key determinant of agonistic antibody efficacy
Jantine E. Bakema and Marjolein van Egmond
Fc receptor dependent mechanisms of monoclonal antibody therapy of cancer; professionals at work
Sybille Böhm, Daniela Kao and Falk Nimmerjahn
Sweet and Sour: The role of glycosylation for the anti-inflammatory activity of immunoglobulin G
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