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The tanning industry is a major source of pollution worldwide, particularly in developing countries. The major public concern over tanneries has traditionally been about odours and water pollution from untreated discharges… Meer
Germ cells in sexually reproducing metazoa, through the germline lineage, are the route by which genetic material and cytoplasmic constituents are passed from one generation to the next in the continuum of life… Meer
This book provides an overview of critical components of cell signaling machinery and its role in epithelial morphogenesis, proliferation, invasions and angiogenesis in human cancer and discusses novel types of protein kinase pathways. Meer
Cardiothoracic Surgery in the Elderly: Evidence Based Practice is an important and timely book that reflects the thoughtful work of pioneers in geriatric surgery. It encompasses their knowledge related to geriatric surgery, and their reflections and guidance on the rapidly accumulating knowledge… Meer
Astroviruses were first identified in the feces of children in 1975. Since then, they have been found in ~ 3 to 20% of children with diarrhea. Given that serological studies have demonstrated that up to 90% of children have been exposed to at least one strain of astrovirus by age 9, the prevalence… Meer
This volume will consider one of ICH’s major categories, Safety i.e. topics relating to in vitro and in vivo pre-clinical studies (Carcinogenicity Testing, Genotoxicity Testing, etc.). Since the start of the ICH process, many guidelines have been written, but even after ICH6 no explanations have… Meer
The discovery of stress-induced mutagenesis has changed ideas about mutation and evolution, and revealed mutagenic programs that differ from standard spontaneous mutagenesis in rapidly proliferating cells… Meer
Germination of the thought of "Enzymatic- and Transporter-Based Drug-Drug Interactions: Progress and Future Challenges" Proceedings came about as part of the annual meeting of The American Association of Pharmaceutical Scientists (AAPS) that was held in San Diego in November of 2007… Meer
TwentyyearshavegonebysinceJackSokatch?rstpublishedhisoutsta- ingTheBiologyofPseudomonasbackin1986.Thiswasfollowedbytwobooks published by the ASM that contained the presentations of the Pseudomonas meetings held in Chicago in 1989 and Trieste in 1991… Meer
Signal transduction pathways are at the core of most biological processes and are critical regulators of heart physiology and pathophysiology. The heart is both a transmitter and dynamic receptor of a variety of intracellular and extracellular stimuli, playing a critical role of an integrator of… Meer
This book is intended to serve as a resource for analysts in developing and troubleshooting sample preparation methods. These are critical activities in providing accurate and reliable data throughout the lifecycle of a drug product… Meer
Sequential Experimentation in Clinical Trials: Design and Analysis is developed from decades of work in research groups, statistical pedagogy, and workshop participation. Different parts of the book can be used for short courses on clinical trials, translational medical research, and sequential… Meer
Bladder Pain Syndrome: A Guide for Clinicians provides a comprehensive update in the pathophysiology, epidemiology, terminology, evaluation and treatment of patients with pelvic pain perceived to be related to the urinary bladder… Meer
Sexual risk behaviors have inspired profound ideas and effective teamwork. But as the early history of AIDS demonstrates, when sexual practice is part of the equation, the same bold thinkers may be stymied, or just silent… Meer
Book chapters are authored by participants in the International Meeting on Staging Neuropsychiatric Disorders: Implications for Etiopathogenesis and Treatment , held in Mojácar (Almería) Spain from 14-18 October 2009… Meer
This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host. Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and… Meer
Among U. S. racial and ethnic minority populations, African American communities are the most disproportionately impacted and affected by HIV/AIDS (CDC, 2009; CDC, 2008). The chapters in this volume seek to explore factors that contribute to this disparity as well as methods for intervening and… Meer
Hormone Receptors in Breast Cancer provides an up-to-date resource of the role of hormone receptors in breast cancer written in depth for both the basic molecular academic researcher and translational scientist… Meer
This book presents new insights into Freud’s famous “discovery” of the unconscious and the subsequent development of psychoanalytic theories. The authors explore the original context in which these ideas arose and the central debate about mind as matter or something that transcends matter… Meer
In the biomedical field, biomedical imaging has come to be a discipline of its own, given the nature of its applications in the understanding of the human body and medical diagnostics. The understanding of Deformable Models are the significant utility on biomedical imagery primarily because of its… Meer
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