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This book centers on gene therapy and gene transfer approaches to prevent or treat chronic virus infections. The main focus is on the Big Three: human immunodeficiency virus (HIV-1), hepatitis B virus (HBV) and hepatitis C virus (HCV)… Meer
In the last few years, significant advances have been made in understanding how a yeast cell responds to the stress of producing a recombinant protein, and how this information can be used to engineer improved host strains… Meer
This volume complies a set of Data Mining techniques and new applications in real biomedical scenarios. Chapters focus on innovative data mining techniques, biomedical datasets and streams analysis, and real applications… Meer
This volume offers a comprehensive guide on the theory and practice of amorphous solid dispersions (ASD) for handling challenges associated with poorly soluble drugs. In twenty-three inclusive chapters, the book examines thermodynamics and kinetics of the amorphous state and amorphous solid… Meer
Melanocytic Lesions: A Case Based Approach provides a concise yet comprehensive guideline on how to diagnose common as well as problematic and challenging melanocytic lesions. In the first 11 chapters, each entity is illustrated by an actual case; followed by discussion of how the diagnosis is… Meer
Chronic Abdominal Pain is a comprehensive resource focused on the management of chronic abdominal pain. Chapters begin with an overview of pain generation, adaptive mechanisms and various diagnostic approaches… Meer
This book presents the basic principles and new and emergent clinical applications of BOLD fMRI. It describes the physical principles of BOLD fMRI imaging and reviews scanning methodologies, data analysis, challenges and limitations of BOLD fMRI, neurovascular uncoupling, and functional… Meer
Current pharmaceutical and clinical approaches to the treatment of disease suffer from the inherent limitations in the specialization of drugs introduced to physiological systems. The interface of clinical and material sciences has allowed for a broad spectrum of creative approaches with the… Meer
Thyroid hormone plays an important role in development and functional maintenance in the central nervous system. Deficiency of thyroid hormone during fetal and early postnatal life induces abnormal development known as cretinism in humans… Meer
The heart has a very high energy demand but very little energy reserves. In order to sustain contractile function, the heart has to continually produce a large amount of ATP. The heart utilizes free fatty acids mainly and carbohydrates to some extent as substrates for making energy and any change in… Meer
The volume aims at providing an overview of cutting-edge methods and protocols used in neuroscience and neurological research. Neurotransmitter Transporters: Investigative Methods will be of interest to scientists, graduate students, and advanced undergraduates who seek an overview of methods and… Meer
This volume provides properties, biological function, methods, and approaches for manipulating nAChRs in different organisms. Nicotinic Acetylcholine Receptor Technologies guides readers through molecular techniques and behavioral tests used to investigate nicotinic drugs, chronoamperometry… Meer
This volume reviews the evolution of information regarding the epidemiology of DCIS and its modes of detection, as well as treatment options as a function of both clinical trial data and ongoing investigational therapeutic prospects… Meer
This volume presents the latest protocols for both laboratory and bioinformatics based analyses in the field of marine genomics. The chapters presented in the book cover a wide range of topics, including the sampling and genomics of bacterial communities, DNA extraction in marine organisms… Meer
This volume educates physicians on the basic knowledge of ESD, from indication of this technique to assessing suitability and technical aspects of each important step. The text is structured to guide readers to understand the principles, including history, why ESD was designed and developed… Meer
This book provides a comprehensive, state-of-the art review of the genitourinary tumor pathology field and the most contemporary insights regarding specimen submission, histologic morphology, immunohistochemistry, and molecular studies useful in the diagnosis of genitourinary neoplasms… Meer
Receptor Tyrosine Kinase: Structure, Functions and Role in Human Disease , for the first time, systematically covers the shared structural and functional features of the RTK family. Receptor Tyrosine Kinases (RTKs) play critical roles in embryogenesis, normal physiology and several diseases… Meer
This volume provides an overview of advanced fluorescence microscopy, covering a broad range of methods. Each chapter focuses on a different method and provides a practical guide for application in biological systems… Meer
This unique title is designed to illustrate and foster how a closer working relationship between pediatricians and subspecialists can make childhood medicine work more seamlessly. Despite the common lack of training for pediatricians in pediatric neurosurgery, they are challenged almost daily with… Meer
Stem Cell therapy for lysosomal diseases (LSDs) is developing rapidly. This volume discusses the history, current practice and future perspectives of stem cells in inborn errors of metabolism (IEM) and provides an international perspective on progress, limitations, and future directions (e.g. gene… Meer
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