The Oncogene and Tumour Suppressor Gene Factsbook

The Introductory Chapters:<br>Introduction: Identification of Oncogenes.<br>Oncogene Activation in Humans.<br>Proliferation Control Pathways: Oncoprotein Function.<br>Growth Factor-Related Proteins.<br>SRC. RAS and RAF.<br>Nuclear Oncoproteins.<br>ETS. FOS and JUN. MYB. MYC. REL. ERBA.<br>Tumour Suppressor Genes: RB1. P53.<br>Other Major Tumour Suppressor Genes.<br>APC. BRCA1. NF1. VHL. WT1.<br>Cell Cycle Control: Cyclin-Dependent Kinase Inhibitors (CDKIs).<br>Apoptosis: Tumour Suppressor Genes and Apoptosis.<br>DNA Repair.<br>Angiogenesis and Metastasis: Angiogenesis.<br>Angiogenic Promoters.<br>Angiogenic Inhibitors.<br>Metastasis: Correlations with Gene Expression.<br>Cadherins.<br>The Immunoglobulin Superfamily (IgSF), Neural Cell-Adhesion Molecule (NCAM).<br>Integrins.<br>CD44.<br>Matrix Metalloproteinases (MMPS).<br>Tissue Inhibitors of Metalloproteinases (TIMPs).<br>Cysteine and Aspartic Proteinases and Heparanase.<br>NME1 and NME2.<br>The Multi-step Nature of Cancer: Cervical Carcinoma.<br>Colorectal Carcinoma.<br>Breast Carcinoma.<br>Prostate Carcinoma.<br>Renal Cell Carcinoma.<br>Lung Carcinoma.<br>Lymphomas.<br>Chronic Myeloid Leukemia.<br>Gene Therapy for Cancer: Nucleotide Sequence-Targeted Strategies.<br>Tumour Suppressor Gene Therapy.<br>Cytokine Gene Therapy and Tumour Vaccination.<br>Virally Directed Enzyme Prodrug Therapy (VDEPT).<br>Antibody-directed Therapy.<br>Tables:<br>Oncogenes Transduced by Retroviruses.<br>Oncogenes Activated by Retroviral Insertion.<br>Oncogenes at Chromosomal Translocations.<br>Tumour Suppressor Genes Detected in Human Tumours.<br>Functions of Oncoproteins.<br>Chromosome Locations of Human Proto-Oncogenes and Tumour Suppressor Genes.<br>The Oncogenes:<br>ABL. AKT1 and AKT2. BCL2. BCL3. BCR. CBL. CDK4. CRK. CSFIR/FMS. D Cyclins. DBL. EGFR/ErbB. ELK1. EPH. ERG. ETS1 and ETS2. FGR. FLII. FOS. FOSB. FPS/FES. FRA1 and FRA2. FYN. HCK. HER2/ErbB-2/Neu. HER3/ErbB-3. HER4/ErbB-4. HSTF1/HST2. INT2. JUN. JUNB. JUND. KIT. LCK. LYN. MAS. MAX. MET. Mil. MOS. MYB. MYC. PDGF/Sis. PIM1. RAF. RAS. REL. RET. ROS1. SEA. SKI. SRC. TAL1. THRA/ErbA-1 and THRA2/ErbA-2. TIAM1. TRK. VAV. WNT1. WNT2 and WNT3. YES1.<br>Tumour Suppressor Genes:<br>APC and MCC. BRCA1 and BRCA2. DCC. DPC4. E2F1. E-cadherin/CDH1. MSH2. MSH3. MSH6/GTBP and MLHL. NF1 and NF2. P53, PTC.<br>The Retinoblastoma Gene (RB1). TGFBR1 and TGFBR2. VHL; WT1.<br>Cyclin-dependent Kinase Inhibitors:<br>INK4A/MTS1/MTS2/CDK41/CDKN2. INK4B/MTS2.<br>INK4C and INK4D. KIP1. KIP2. WAF1.<br>DNA Tumour Viruses:<br>Human Papillomaviruses.<br>Epstein-Barr Virus.<br>Subject Index.