Esteban Domingo,
Colin R. Parrish,
John J. Holland
Origin and Evolution of Viruses
Gebonden Engels 2008 9780123741530Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
New viral diseases are emerging continuously. Viruses adapt to new environments at astounding rates. Genetic variability of viruses jeopardizes vaccine efficacy. For many viruses mutants resistant to antiviral agents or host immune responses arise readily, for example, with HIV and influenza. These variations are all of utmost importance for human and animal health as they have prevented us from controlling these epidemic pathogens. This book focuses on the mechanisms that viruses use to evolve, survive and cause disease in their hosts. Covering human, animal, plant and bacterial viruses, it provides both the basic foundations for the evolutionary dynamics of viruses and specific examples of emerging diseases.
Specificaties
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Inhoudsopgave
1. Early Replication: Origin and Evolution<br>2. Structure and Evolution of Viroids<br>3. Mutation, Competition and Selection as Measured with Small RNA Molecules<br>4. Viral Quasispecies: Dynamics, Interactions and Pathogenesis<br>5. Comparative Studies of RNA Virus Evolution<br>6. Nucleic Acid Polymerase Fidelity and Viral Population Fitness<br>7. The complex Interactions of Viruses and the RNAi Machinery: A Driving Force in Viral Evolution<br>8. The Role of the APOBEC3 Family of Cytidine Deaminases in Innate Immunity, G-to-A Hypermutation<br>9. Lethal Mutagenesis<br>10. Evolution of dsDNA Tailed Phages<br>11. More about Plant Virus Evolution – Past, Present and Future<br>12. Mutant clouds and bottleneck events in plant virus evolution<br>13. Retrovirus Evolution<br>14. Intra-host dynamics and evolution of HIV Infection<br>15. The Impact of Rapid Evolution of Hepatitis Viruses<br>16. Arbovirus Evolution<br>17. Evolution and Variation of the Parvoviruses<br>18. Genome Diversity and Evolution of Papillomaviruses<br>19. Origin and Evolution of Poxviruses<br>20. Molecular Evolution of the Herpesvirales<br>21. The widespread evolutional significance of viruses
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