John E. Macor
Annual Reports in Medicinal Chemistry
Paperback Engels 2010 9780123809025Levertijd ongeveer 9 werkdagen
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Samenvatting
Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies.
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Inhoudsopgave
Section I: Central Nervous System Diseases – ROBICHAUD
Shridhar Hegde and Michelle Schmidt
- Voltage-Gated Calcium Channel Antagonists for the Central Nervous System James C. Barrow and Joseph L. Duffy
- Recent Developments in Glycine Transporter-1 Inhibitors Christopher L. Cioffi, Shuang Liu and Mark A.Wolf
- Modulators of Transient Receptor Potential Ion Channels Rajagopal Bakthavatchalam and S. David Kimball
- Defining Neuropharmacokinetic Parameters in CNS Drug Discovery to Determine Cross-species Pharmacologic Exposure-Response Relationships Christopher L. ShafferSection II: Cardiovascular and Metabolic Diseases - STAMFORD
- High Affinity Niacin Receptor GPR109A Agonists Hong C. Shen and Steven L. Colletti
- Recent Advances in Acetyl CoA Carboxylase (ACC) Inhibitors Matthew P. Bourbeau, John G. Allen, and Wei Gu
- Enzymatic Targets in the Triglyceride Synthesis Pathway Dmitry O. Koltun and Jeff Zablocki
- Inhibitors of HIF Prolyl Hydroxylases Michael H. Rabinowitz, Terrance D. Barrett, Mark D. Rosen, Hariharan VenkatesanSection III: Inflammation / Pulmonary / GI - BARRISH/Weinstein
- Opioid Receptor Antagonists for Gastrointestinal Dysfunction R. William Hipkin and Roland E. Dolle
- CFTR Modulators for the Treatment of Cystic Fibrosis Sabine Hadida, Frederick Van Goor and Peter D. J. Grootenhuis
- Targeting B-cells in inflammatory disease Kevin S. Currie
- Modulators of Toll-Like Receptor (TLR) Signaling Mark Spyvee, Lynn Hawkins, and Sally IshizakaSection IV: Oncology - McAlpine
- Janus Kinase 2 (JAK2) inhibitors for the treatment of myeloproliferative neoplasm (MPN) Ashok V. Purandare, Matthew V. Lorenzi and Louis J. Lombardo
- Development of poly(ADP-ribose)polymerase (PARP) inhibitors in oncology Philip Jones
- Epigenetic Targets and Cancer Drug Discovery Patrick M. Woster, Ph.DSection V: Infectious Diseases - Primeau
- HIV-1 Integrase Strand Transfer Inhibitors Brian A. Johns
- Recent Advances in Drug Discovery for Neglected Tropical Diseases Caused by Infective Kinetoplastid Parasites Robert T. Jacobs and Charles Ding
- Recent Advances in the Inhibition of Bacterial Fatty Acid Biosynthesis Vincent GeruszSection VI: Topics in Biology - LOWE
- Back to the Plaque: Emerging Studies That Re-Focus Attention on the Neuritic Plaque in Alzheimer’s Disease Dr. Robert B. Nelson
- Targeting Methyl Lysine Stephen V. Frye, Tom Heightman and Jian Jin
- Chemical Proteomic Technologies for Drug Target Identification Kieran F. Geoghegan and Douglas S. Johnson
- NIH Translational Programs for Assisting Pre-Clinical Drug Discovery and Development Raj N. MisraSection VII: Topics in Drug Design and Discovery - DESAI
- Role of Physicochemical Properties and Lipophilic Ligand Efficiency (LipE or LLE) in addressing Drug Safety Risks Martin P. Edwards and David A. Price
- Reducing the Risk of Drug Attrition Associated with Physicochemical Properties Paul D. Leeson and James R. Empfield
- Compound Collection Enhancement and Paradigms for High Throughput Screening - an Update Stevan W Djuric, Irini Akritopoulou-Zanze, Philip B Cox and Scott Galasinski
- The Role of Fluorine in the Discovery and Optimization of CNS Agents: Modulation of Drug-Like Properties Kevin J. Hodgetts, Kerry J. Combs, Amy M. Elder and Geraldine C. Harriman
- Patents in Drug Discovery: Case Studies, Examples, and Simple Steps Medicinal Chemists Can Take to Protect Hard-Won Intellectual Property Charles J. Andres, Jr. and Richard L. TreanorSection VIII: Trends and Perspectives
- To Market, To Market – 2009
Shridhar Hegde and Michelle Schmidt
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