G Protein Coupled Receptors

Structure

Gebonden Engels 2013 9780123918611
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This new volume of Methods in Enzymology continues the legacy of this premier serial by containing quality chapters authored by leaders in the field. This volume covers G protein coupled receptors and includes chapters on such topics as post-translation modification of GPCR in relationship to biased agonism, structure-based virtual screening, and GPCR oligomerization in the brain.

Specificaties

ISBN13:9780123918611
Taal:Engels
Bindwijze:Gebonden

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Inhoudsopgave

    1. G Protein Coupled Receptors: Techniques for Probing Structure
    2. Comformational Ensemble View of G Protein-Coupled Receptors and The Effect of Mutations and Ligand Binding
    3. Structural Evolution of G-Protein-Coupled Receptors: A Sequence Space Approach
    4. Directed Evolution of G Protein-Coupled Receptors for High Functional Expression and Detergent Stability
    5. The Role of Hydrophobic Amino Acids in the Structure and Function of the Rhodopsin Family of G Protein-Coupled Receptors
    6. Structure of β-Adrenergic Receptors
    7. Advances in Methods to Characterize Ligand-Induced Ionic Lock and Rotamer Toggle Molecular Switch in G-Protein Coupled Receptors
    8. Crystallogenesis of Adenosine A2A Receptor – T4 Lysozyme Fusion Protein: A Practical Route for the Structure
    9. Probing GPCR Structure: Adenosine and P2Y Nucleotide Receptors
    10. Strategies for Studying the Ligand Binding Site of GPCRs: Photoaffinity Labeling of the VPAC1 Receptor, a Prototype of Class B GPCRs
    11. Expression of Mammalian G Protein-Coupled Receptors in Caenorhabditis Elegans
    12. Expression, Purification and Structural Analysis of Intracellular C-Termini from Metabotropic Glutamate Receptors
    13. Unnatural Amino Acid Mutagenesis of GPCRs Using Amber Codon Suppression and Bioorthogonal Labeling
    14. Mapping a Ligand Binding Site Using Genetically-Encoded Photoactivatable Crosslinkers
    15. Alternative mRNA Splicing of G Protein-Coulped Receptors
    16. Functional Residues of the CB1 Cannabinoid Receptor
     

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€ 194,75
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          G Protein Coupled Receptors