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Pharmacogenomics

Challenges and Opportunities in Therapeutic Implementation

Gebonden Engels 2013 9780123919182
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Samenvatting

Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.

Specificaties

ISBN13:9780123919182
Taal:Engels
Bindwijze:Gebonden
Aantal pagina's:510

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Inhoudsopgave

SECTION 1

1 Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications
2 Translating Pharmacogenomic Research to Therapeutic Potentials
3 Governmental and Academic Efforts to Advance the Field of Pharmacogenomics (PGRN CPIC, PharmGKB)

Section 2

4a Pharmacogenomics in Cancer Therapeutics
4b A Look to the Future:  Cancer epigenetics
5a Pharmacogenomics in Cardiovascular Diseases
5b A Look to the Future: Cardiovascular Pharmaco-epigenetics
6a Pharmacogenomics in Psychiatry Disorders
6b A Look to the Future: Epigenetics in psychiatric disorders and treatment
7 Role of Pharmacogenomics in Diabetes and Other Therapeutic Areas 

SECTION 3

8a Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development
8b Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development
9a Incorporating Pharmacogenomics in Drug Development
Part 1:  Rational  study designs for pharmacogenetic research and therapy - A perspective  from academia
9b Incorporating Pharmacogenomics in Drug Development
Part 2:  A perspective from industry
10 Ethnobridging and Pharmacogenomics

SECTION 4

11 Beyond ELSIs - Where to from here? From 'Regulator' to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine
12 The Economics of Pharmacogenomics

SECTION 5

13 Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics is not enough

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          Pharmacogenomics