Primary Immunodeficiency Disorders

Foreword<br>Introduction<br>1. Immunity: From Serendipitous Observations To Science-Based Speciality<br>2. The Discovery Of The T And B Cell Compartments<br>3. Evolution Of The Definition Of Primary Immunodeficiencies<br>4. From Immunodeficiency To Autoimmunity <br>5. Immunological Tests – From The Microscope To Whole Genome Analysis<br>6. Primary Immunodeficiency In The Developing Countries<br>7. From A Sad Family History To A Worldwide Recognition<br>8. Finally Found: The Ataxia-Telangiectasia Gene and Its Function<br>9. Wiskott-Aldrich Syndrome: From A Fatal Hematologic Disorder To A Curable Immunodeficiency <br>10.Neutropenia – More Genetic Defects Than Ever Expected<br>11.B Cell Defects - From X Linked To Autosomal Recessive Agammaglobulinemia <br>12.The Discovery Of The Familial Hemophagocytosis Syndromes <br>13.Chronic Granulomatous Disease – From A Fatal Disease To A Curable One<br>14.Severe Combined Immunodeficiency - From Discovery To Newborn Screening<br>15.Cytokine Defects – How They Cause Severe Combined Immunodeficiency <br>16.The Hyper IgM Syndromes – A Long List Of Genes And Years Of Discovery<br>17.Unraveling The Complement System and Its Mechanism Of Action<br>18.The DiGeorge Syndrome: A Serendipitous Discovery<br>19.The Many Faces Of The Hyper IgE Syndrome<br>20.ADA Deficiency – The First Described Genetic Defect Causing PID<br>21.The Leukocyte Adhesion Deficiency Story<br>22.How Common Variable Immune Deficiency Has Changed Over Six Decades<br>23.From Subcutaneous To Intravenous Immunoglobulin And Back<br>24.History of Hematopoietic Stem Cell Transplantation<br>25.David's Story <br>26.How Primary Immunodeficiencies Have Made Gene Therapy A Reality