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Personalized Immunosuppression in Transplantation

Role of Biomarker Monitoring and Therapeutic Drug Monitoring

Gebonden Engels 2015 9780128008850
Verwachte levertijd ongeveer 9 werkdagen

Samenvatting

Personalized Immunosuppression in Transplantation: Role of Biomarker Monitoring and Therapeutic Drug Monitoring provides coverage of the various approaches to monitoring immunosuppressants in transplant patients, including the most recently developed biomarker monitoring methods, pharmacogenomics approaches, and traditional therapeutic drug monitoring.

The book is written for pathologists, toxicologists, and transplant surgeons who are involved in the management of transplant patients, offering them in-depth coverage of the management of immunosuppressant therapy in transplant patients with the goal of maximum benefit from drug therapy and minimal risk of drug toxicity.

This book also provides practical guidelines for managing immunosuppressant therapy, including the therapeutic ranges of various immunosuppressants, the pitfalls of methodologies used for determination of these immunosuppressants in whole blood or plasma, appropriate pharmacogenomics testing for organ transplant recipients, and when biomarker monitoring could be helpful.

Specificaties

ISBN13:9780128008850
Taal:Engels
Bindwijze:Gebonden

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Inhoudsopgave

<p>Chapter 1. Overview of the pharmacology and toxicology of immunosuppressant agents that require therapeutic drug monitoring</p> <p>Chapter 2. Limitations of Immunoassays Used for Therapeutic Drug Monitoring of Immunosuppressants</p> <p>Chapter 3. Application of liquid chromatography combined with mass spectrometry or tandem mass spectrometry for therapeutic drug monitoring of immunosuppressants</p> <p>Chapter 4. Monitoring Free Mycophenolic Acid Concentration: Is There any Clinical Advantage?</p> <p>Chapter 5. Pharmacogenomics aspect of immunosuppressant therapy</p> <p>Chapter 6. Biomarker monitoring in immunosuppressant therapy: An overview</p> <p>Chapter 7. Graft-derived cell-free DNA as a Marker of Graft Integrity after Transplantation</p> <p>Chapter 8. Biomarkers of tolerance in kidney transplantation</p> <p>Chapter 9. Intracellular concentrations of immunosuppressants</p> <p>Chapter 10. Markers of lymphocyte activation and proliferation</p> <p>Chapter 11. Monitoring Calcineurin inhibitors response based on NFAT-regulated gene expression</p>

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        Personalized Immunosuppression in Transplantation