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Yi Yang, Yi (PhD, Senior Research Scientist, Chemical Development, Global Pharmaceutical R&D, Ferring Pharmaceuticals A/S, Copenhagen, Denmark) Yang

Side Reactions in Peptide Synthesis

Name: Side Reactions in Peptide Synthesis
Author: Yi Yang

Gebonden Engels 2015 9780128010099

€ 92,14

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Samenvatting

Side Reactions in Peptide Synthesis, based on the author’s academic and industrial experience, and backed by a thorough review of the current literature, provides analysis of, and proposes solutions to, the most frequently encountered side reactions during peptide and peptidomimetic synthesis.

This valuable handbook is ideal for research and process chemists working with peptide synthesis in diverse settings across academic, biotech, and pharmaceutical research and development.

While peptide chemistry is increasingly prevalent, common side reactions and their causes are often poorly understood or anticipated, causing unnecessary waste of materials and delay.

Each chapter discusses common side reactions through detailed chemical equations, proposed mechanisms (if any), theoretical background, and finally, a variety of possible solutions to avoid or alleviate the specified side reaction.

Specificaties

ISBN13:9780128010099

Taal:Engels

Bindwijze:Gebonden

Uitgever:Elsevier Science

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Inhoudsopgave

<ol> <li>Peptide Fragmentation/Deletion</li> <li>Premature FMOC Deprotection</li> <li>Elimination Side Reactions</li> <li>Peptide Global Deprotection/Scavenger-Induced Side Reactions</li> <li>Peptide Rearrangement Side Reactions</li> <li>Side Reactions Occurring at Amino Acid/Peptide Activation Step</li> <li>Intramolecular Cyclization Side Reactions</li> <li>Side Reactions in Amino Groups in Peptide Synthesis</li> <li>Side Reactions in Hydroxyl, Carboxyl, Ester Groups in Peptide Synthesis </li> <li>Oxidation and Reduction Side Reactions in Peptide Synthesis</li> <li>Racemization in Peptide Synthesis</li> <li>Solvent and Residual Impurities in the Reagents Induced Side Reactions</li> <li>Dipeptide Formation Side Reactions (Redundant Amino Acid Incorporation)</li> <li>Reattachment of Peptides to the Solid Supports</li> <li>Addition Side Reactions in Peptide Synthesis</li> <li>Side Reactions in Phosphor Peptides</li> <li>Side Reactions in CYS</li> <li>Protein Fragmentations</li></ol>

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