Drug Discovery in Cancer Epigenetics

Preface<br>I. Introduction <br>1: Basic Epigenetic Mechanisms and Phenomena<br>2: Cancer Epigenetics<br>II. Methods and Tools for Epigenetic Drug Development<br>3: Drug Discovery Methods<br>4: Preclinical Cancer Models with the Potential to Predict Clinical Response<br>5: Discovery of Biomarkers for Drug Development<br>6: Networks and Consortia for Epigenetic Drug Discovery<br>III. Classes of Epigenetic Drugs<br>7: DNA Methyltransferase Inhibitors<br>8: Small Molecule Inhibitors of Histone Deacetylases and Acetyltransferases as Potential Therapeutics in Oncology<br>9: Targeting histone methylation. The development of selective methyltransferase and demethylase inhibitors<br>10: Bromodomains as Anti-Cancer Targets<br>11: Epigenetic Readers Interpreting the Lysine Methylome – Biological Roles and Drug Discovery<br>12: Non coding RNAs: Clinical and Therapeutic Applications<br>IV. Clinical Implications of Epigenetic Therapy<br>13: Clinical Applications of Epigenetic Drugs<br>14: Efficacy of Combined Epigenetic Therapies<br>15: Predicting and Monitoring Responses to Epigenetic Drugs<br>16: Episensitization: A New Word for A New Concept<br>17: The Emerging Potential for Epigenetic Therapeutics in Non-Cancer Disorders<br>