Cannabinoids and Their Receptors

Gebonden Engels 2017 9780128121566
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Cannabinoids and Their Receptors, Volume 593, the latest release in the Methods in Enzymology series, continues the legacy of this premier serial with quality chapters authored by leaders in the field. This updated volume includes comprehensive chapters on a variety of topics, including Real time cAMP signaling in response to CB1 activation, CB1 signaling in mitochondria, Lipidomics of cannabinoid systems, Studying endocannabinoid transport, Metabolic profiling of CB1 neutral antagonists, Approaches to assess biased signaling at the CB1 receptor, and the Development of CB1 allosteric modulators.

Specificaties

ISBN13:9780128121566
Taal:Engels
Bindwijze:Gebonden

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Inhoudsopgave

<p>1. Mouse Neuroblastoma CB1 Cannabinoid Receptor-Stimulated [35S]GTPɣS Binding: Total and Antibody-Targeted Gα Protein-Specific Scintillation Proximity Assays<br>2. Protocols and Good Operating Practices in the Study of Cannabinoid Receptors<br>3. Real-Time Measurement of Cannabinoid Receptor-Mediated cAMP Signaling<br>4. Techniques for the Cellular and Subcellular Localization of Endocannabinoid Receptors and Enzymes in the Mammalian Brain<br>5. Endocannabinoid Transport Proteins: Discovery of Tools to Study Sterol Carrier Protein-2<br>6. Lipidomics: A Corrective Lens for Enzyme Myopia<br>7. Functional Analysis of Mitochondrial CB1 Cannabinoid Receptors (mtCB1) in the Brain<br>8. Modeling Neurodegenerative Disorders for Developing Cannabinoid-Based Neuroprotective Therapies<br>9. Metabolic Profiling of CB1 Neutral Antagonists<br>10. Ligand-Assisted Protein Structure (LAPS): An Experimental Paradigm for Characterizing Cannabinoid-Receptor Ligand-Binding Domains<br>11. New Methods for the Synthesis of Cannabidiol Derivatives<br>12. Approaches to Assess Biased Signaling at the CB1R Receptor<br>13. Design and Synthesis of Cannabinoid 1 Receptor (CB1R) Allosteric Modulators: Drug Discovery Applications<br>14. Assessing Allosteric Modulation of CB1 at the Receptor and Cellular Levels<br>15. Purification of Functional CB1 and Analysis by Site-Directed Fluorescence Labeling Methods<br>16. Mass Spectrometry Analysis of Human CB2 Cannabinoid Receptor and Its Associated Proteins<br>17. Expression and NMR Structural Studies of Isotopically Labeled Cannabinoid Receptor Type II<br>18. Methods for the Development of In Silico GPCR Models<br>19. Molecular Dynamics Methodologies for Probing Cannabinoid Ligand/Receptor Interaction</p>

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€ 196,00
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          Cannabinoids and Their Receptors