Modern Approaches in Drug Discovery

<p>1. Risk Management in Early Discovery Medicinal Chemistry <br>Gurpreet Singh, Jayme L. Dahlin and Michael A. Walters<br>2. Target Identification Using Chemical Probes<br>Moses Moustakim, Suet Ling Felce, Nancy Zaarour, Gillian Farnie, Fiona E. McCann and Paul E. Brennan<br>3. Mining the Microbiome for Drug Targets<br>Qi Wang, Fangming Yang and Huijue Jia<br>4. Screening Library Design<br>Stephanie Kay Ashenden<br>5. Design of a Fragment Screening Library<br>Ashley Taylor, Bradley C. Doak and Martin J. Scanlon<br>6. Genetically Encoded Cyclic Peptide Libraries: From Hit to Lead and Beyond<br>Jacob Valentine and Ali Tavassoli<br>7. A Guide to Run Affinity Screens Using Differential Scanning Fluorimetry and Surface Plasmon Resonance Assays<br>Christian Bergsdorf and Kirk Wright<br>8. Second-Harmonic Generation (SHG) for Conformational Measurements: Assay Development, Optimization, and Screening<br>Tracy A. Young, Ben Moree, Margaret T. Butko, Bason Clancy, Mary Geck Do, Tarun Gheyi, John Strelow, Juan J. Carrillo and Joshua Salafsky<br>9. An Array-Based Ligand Discovery Platform for Proteins With Short Half-Lives<br>Becky S. Leifer, Shelby K. Doyle, André Richters, Helen L. Evans and Angela N. Koehler<br>10. High Content, Phenotypic Assays and Screens for Compounds Modulating Cellular Processes in Primary Neurons<br>Miklos Kepiro, Boglarka H. Varkuti and Ronald L. Davis<br>11. Achieving a Good Crystal System for Crystallographic X-Ray Fragment Screening<br>Patrick M. Collins, Alice Douangamath, Romain Talon, Alexandre Dias, Jose Brandao-Neto, Tobias Krojer and Frank von Delft<br>12. Hit-to-Lead: Hit Validation and Assessment<br>Kirk E. Hevener, JinHong Ren, Russell Pesavento, Kiira Ratia, Hyun Lee and Michael E. Johnson<br>13. Knowledge-Based Approaches to Off-Target Screening<br>Daniel R. McMasters</p>