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Organ-on-a-chip

Engineered Microenvironments for Safety and Efficacy Testing

Paperback Engels 2019 9780128172025
€ 190,60
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Samenvatting

Organ-on-a-Chip: Engineered Microenvironments for Safety and Efficacy Testing contains chapters from world-leading researchers in the field of organ on a chip development and applications, with perspectives from life sciences, medicine, physiology and engineering. The book contains an overview of the field, with sections covering the major organ systems and currently available technologies, platforms and methods. As readers may also be interested in creating biochips, materials and engineering best practice, these topics are also described.

Users will learn about the limitations of 2D in-vitro models and the available 3D in-vitro models (what benefits they offer and some examples). Finally, the MOC section shows how the organ on a chip technology can be adapted to improve the physiology of in-vitro models.

Specificaties

ISBN13:9780128172025
Taal:Engels
Bindwijze:Paperback

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Inhoudsopgave

<p>1. Need for alternative testing methods and opportunities for organ-on-a-chip systems<br>2. Cell sources and methods for producing organotypic in vitro human tissue models<br>3. Organs-on-a-chip engineering</p> <p>Part I Organ-on-a-chip platforms to model disease pathogenesis<br>4. Lung-on-a-chip platforms for modeling disease pathogenesis<br>5. Requirements for designing organ-on-a-chip platforms to model the pathogenesis of liver disease<br>6. Brain-on-a-chip systems for modeling disease pathogenesis<br>7. Kidney-on-a-chip<br>8. Heart-on-a-chip<br>9. Caenorhabditis elegans-on-a-chip: microfluidic platforms for high-resolution imaging and phenotyping<br>10. Gut-on-a-chip microphysiological systems for the recapitulation of the gut microenvironment<br>11. Computational pharmacokinetic modeling of organ-on-chip devices and microphysiological systems</p> <p>Part II Multi-organs-on-a-chip platforms to mimic humans physiology<br>12. Design and engineering of multiorgan systems<br>13. 8.b. Human body-on-a-chip systems<br>14. Automation and opportunities for industry scale-up of microphysiological systems<br>15. How to build your multiorgan-on-a-chip system: a case study</p>

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€ 190,60
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