Fibroblast Growth Factor 23

<p>1. The discovery of FGF23 – a historic view: genetic disorders of hypo- and hyperphosphatemia<br>2. FGF23 – an established master regulator of phosphate metabolism<br>3. FGF23 – more than a phosphaturic hormone<br>4. The regulation of FGF23 production in bone and outside of bone<br>5. Klotho-dependent actions of FGF23 - targets, signal transduction and cellular effects<br>6. Klotho-independent actions of FGF23 - targets, signal transduction and cellular effects<br>7. The experimental detection of FGF23 responsiveness and effects<br>8. FGF23 and bone disease<br>9. FGF23 and kidney disease<br>10. FGF23 and heart and vascular disease<br>11. FGF23 and inflammation, anemia, and iron<br>12. FGF23 and infectious diseases<br>13. FGF23 and lung disease<br>14. FGF23 and neuro-cognitive disorders<br>15. FGF23 as a drug target<br>16. FGF23 – resolved issues, remaining controversies and future questions – a clinician’s perspective<br>17. Klotho – the discovery of the FGF23 co-receptor<br>18. Klotho – an FGF23-independent hormone<br>19. Klotho and aging phenotypes<br>20. αKlotho gene and protein measurements in humans and their role as a clinical biomarker of disease <br>21. Structural Basis of FGF23 Hormone Signaling<br>22. Klotho – open questions, controversies and future perspectives<br>23. The crosstalk between phosphate, FGF23 and klotho in the regulation of tissue homeostasis in health and disease</p>