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Peptide and Peptidomimetic Therapeutics

From Bench to Bedside

Paperback Engels 2022 9780128201411
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Peptide and Peptidomimetic Therapeutics: From Bench to Beside offers applied, evidence-based instruction on developing and applying peptide therapeutics in disease treatment, driving drug discovery, and improving patient care. Here, researchers, clinicians and students will find tools to harness the full power of peptides and peptidomimetics and improve bioavailability, stability, efficiency and selectivity of new therapeutics and their application in treatment plans. More than 20 leaders in the field share their approaches for identifying and advancing peptide and peptidomimetic therapeutics. Topics examined run from "bench to bedside," beginning with fundamental peptide science, protein-protein interactions and peptide synthesis.

Later chapters examine modes for peptide drug delivery, including cell penetration peptide and peptidomimetic delivery, as well as the targeting of specific disease types, peptide therapeutics as applied to infectious disease, cancer, metabolic disorders, neurodegenerative disorders, and skin disorders, and antiparasitic and immunosuppressive peptidomimetics.

Specificaties

ISBN13:9780128201411
Taal:Engels
Bindwijze:Paperback

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Inhoudsopgave

<p>History<br>1. Therapeutic peptides: historical perspectives and current development trends</p> <p>Basic science<br>2. Therapeutic peptidomimetics: targeting the undruggable space<br>3. Tailoring peptides and peptidomimetics for targeting protein-protein interactions<br>4. Advances in peptide synthesis<br>5. Stapled peptidomimetic therapeutics<br>6. Ring closing metathesis</p> <p>Drug discovery<br>7. The current state of backbone cyclic peptidomimetics and their application to drug discovery<br>8. Pharmacokinetics and pharmacodynamics of peptidomimetics<br>9. Formulations of peptides and peptidomimetics<br>10. Cell-penetrating peptides<br>11. Intracellular peptides as drug prototypes<br>12. Applications of computational three-dimensional structure prediction for antimicrobial peptides</p> <p>Therapeutic applications<br>13. Knottin peptidomimetics as therapeutics<br>14. Venom peptidomimetics as therapeutics<br>15. Therapeutic peptides targeting protein kinase: progress, challenges and future directions, featuring cancer and cardiovascular disease<br>16. Therapeutic peptidomimetics for infectious diseases<br>17. Antiparasitic therapeutic peptidomimetics<br>18. Peptides and antibiotic resistance<br>19. Antimicrobial peptides and the skin and gut microbiomes<br>20. Peptide and peptidomimetic based vaccines<br>21. Therapeutic peptidomimetics for cancer treatment<br>22. Immunomodulatory peptidomimetics for multiple sclerosis therapy – the story of glatiramer acetate (Copaxone)<br>23. Therapeutic peptidomimetics in metabolic diseases<br>24. Therapeutic peptidomimetics in anesthesiology<br>25. Cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease<br>26. Non-cardiovascular-derived therapeutic peptidomimetics in cardiovascular disease</p> <p>Drug development<br>27. Clinical and preclinical data on therapeutic peptides<br>28. Therapeutic peptides: manufacturing and market<br>29. Future perspectives on peptide therapeutics</p>

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€ 187,00
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        Peptide and Peptidomimetic Therapeutics