Glioblastoma Resistance to Chemotherapy: Molecular Mechanisms and Innovative Reversal Strategies

<p>1. Overview of glioblastoma biological hallmarks and molecular pathology</p> <p>2. Past and present drug treatments for glioblastoma</p> <p>3. Investigational new drugs against glioblastoma</p> <p>4. Molecular mechanimsms in temozolomide-resistant glioblastoma</p> <p>5. Glioma stem cells and associated molecular mechanisms in Glioblastoma</p> <p>6. Signaling in the tumor microenvironment of therapy-resistant glioblastoma</p> <p>7. Intratumoral heterogeneity associated with glioblastoma drug response and resistance</p> <p>8. Role of apoptosis, autophagy, and the unfolded protein response in glioblastoma chemoresistance</p> <p>9. Role of multidrug resistance in glioblastoma chemoresistance: Focus on ABC transporters</p> <p>10. Role of mitochondrial reactive oxygen species in glioblastoma drug resistance and strategies for therapeutic interventions</p> <p>11. Glioblastoma cell-induced immunosuppression causing chemoresistance</p> <p>12. Role of cell quiescence in glioblastoma cytotoxic resistance and strategies for therapeutic intervention</p> <p>13. The molecular and cellular effects of radiotherapy-induced microenvironment changes on potential chemoresistance in glioblastoma</p> <p>14. Molecular and cellular mechanism in recurrent glioblastoma chemoresistance</p> <p>15. Role of long noncoding RNAs in temozolomide-resistant glioblastoma</p> <p>16. Mechanisms of glioblastoma resistance to antiangiogenic agents and reversal approaches</p> <p>17. Treatment and resistance of glioblastoma to CAR T-cell immunotherapies</p> <p>18. On chip analysis of glioblastoma cell chemoresistance</p> <p>19. Three-dimensional in vitro models to study potentiation of glioblastoma resistance by hypoxia</p> <p>20. Chemoresistance mechanisms in mouse models of glioblastoma</p> <p>21. Therapeutic approaches to overcome temozolomide resistance in glioblastoma</p> <p>22. Understanding signal transduction pathways to overcome targeted therapy resistance in glioblastoma</p> <p>23. Targeting the molecular mechanisms of glioma stem cell resistance to chemotherapy</p> <p>24. Immunotherapy for glioblastoma as a means to overcome resistance to standard therapy</p> <p>25. Role of microRNA therapy in presensitizing glioblastoma cells to temozolomide treatment</p> <p>26. Drug penetration through the blood-brain barrier after radiotherapy: New approaches to bypass glioblastoma chemoresistance</p> <p>27. Nanoparticles beyond the blood-brain barrier for glioblastoma</p> <p>28. Small molecules targeting misfolded mutants of p53 as a rescue strategy to improve glioblastoma chemotherapy</p> <p>29. p53 supplementation as a targeted cancer gene therapy for glioblastoma</p>