Biomaterials Science and Biocompatibility

1 Introduction to Biomaterials Science and Biocompatibility.- Scope of Text.- Structures of Soft and Hard Tissues.- Properties of Tissues.- Structure of Synthetic Materials.- Properties of Synthetic Materials.- Structures and Properties of Cells.- Cellular and Tissue Responses to Materials.- Summary.- 2 Introduction to Structure and Properties of Biological Tissues.- to Principles of Stereochemistry.- Basic Building Blocks.- Stereochemistry of Polymer Chains.- Primary and Secondary Structures of Biological Macromolecules.- Higher-Order Structures.- Structure of Extracellular Matrix Macromolecules.- Cell Membrane Polymers.- Other Polymeric Materials.- Summary.- 3 Introduction to Structure and Properties of Polymers, Metals, and Ceramics.- to Synthetic Materials.- Polymer Structures.- Polymer Mechanical Properties.- Structure of Metals.- Structure of Ceramics.- Structure of Composites.- Materials Degradation.- Summary.- 4 Microscopic and Macroscopic Structure of Tissue.- to Methods for Cellular and Tissue Analysis.- Surface and Internal Linings.- Conduit and Holding Structures.- Parenchymal or Organ-Supporting Structures.- Skeletal Structures.- Summary.- 5 Determination of Physical Structure and Modeling.- Viscosity.- Light Scattering.- Quasi-Elastic Light Scattering.- Ultracentrifugation.- Electron Microscopy.- Determination of Physical Parameters for Biological Macromolecules.- Summary.- 6 Assembly of Biological Macromolecules.- Methods for Studying Self-Assembly Processes.- Collagen Self-Assembly.- Assembly of Cytoskeletal Components.- Actin-Myosin Interaction.- Fibrinogen.- Summary.- 7 Mechanical Properties of Tissues.- to Analysis of Tissue Mechanical Properties.- Mechanical Properties of Collagenous Tissues.- Mechanical Properties of Hard Tissue.- Cellular Biomechanics.- Summary.- 8 Pathobiology and Response to Tissue Injury.- Cellular Components.- Cell Attachment, Proliferation, and Differentiation.- Cellular Adaptation.- Cell Injury.- Summary.- 9 Wound Healing.- Biological Cascades Involved in Healing.- Cells Involved in Wound Healing.- Inflammatory and Immunological Aspects of Wound Healing.- Cell Adhesion Molecules Involved in Wound Healing.- Growth Factors Involved in Wound Healing.- General Wound-Healing Process: Inflammatory Phase.- Capsule Formation Around Implants.- Cartilage Wound Healing.- Tendon and Ligament Healing.- Peripheral Nerve Repair.- Hard Tissue Repair.- Cardiovascular Wound Healing.- Summary.- 10 Pathobiological Responses to Implants.- Pathobiological Complications with Silicone Implants.- Inflammation Induced by Wear Particles.- Complement Activation by Biomaterial Surfaces.- Restenosis After Vascular Stenting.- Thrombosis and Small-Diameter Vascular Grafts.- Ectopic Mineralization of Implants.- Summary.- 11 Tissue Engineering.- to Tissue Engineering.- Immunology of Cell and Tissue Transplantation.- Role of Matrixes and Scaffolds in Cell Transplantation.- Tissue Engineering of External Lining Structures.- Skeletal Tissue Engineering.- Tissue Engineering of Specialized Organs.- Summary.- 12 Future Considerations.- New Directions in Tissue Engineering.- Design of New Polymeric Materials.- Design of Interfaces.- Vascular Device Design.- Summary.