Anilkumar Parambath
Polymers for Oral Drug Delivery Technologies
Paperback Engels 2024 9780443137747Levertijd ongeveer 9 werkdagen
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Samenvatting
Polymers for Oral Drug Delivery Technologies covers the fundamentals of oral drug delivery and various aspects of polymer technology in oral drug delivery, from classification and synthesis, to applications and regulatory factors. It presents the oral delivery of therapeutics for treating a number of diseases, along with the challenges of oral drug administration to assure a predictive and reproducible pharmacokinetic profile of active pharmaceutical ingredients (API).
Polymers play an important role to achieve the targeted release profile consistently of an API in vivo by various functionalities like drug protection from gastric juice, fast release and supersaturation or release within a targeted area of the GI tract.
Specificaties
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Inhoudsopgave
Section A. Fundamentals of Oral Drug Delivery
1. GI tract environment (e.g. gastric juice, bile salts, pH, amylases, proteases etc.)
2. GI tract motility and transport
3. Drug absorption and pre-systemic metabolism and PK modelling
4. In vitro dissolution and predictive release testing
5. Principle characteristics and specification of pharmaceutical polymers
6. Regulatory Aspects of Polymers Used and new polymers for Oral Medication
Section B. Role Polymer Technology in Oral Drug Delivery
7. Classes/types of polymers used in oral delivery (natural, semi-synthetic, synthetic), their chemical structure and general functionalities
8. Role of polymers in Tableting
9. Capsule forming Polymers
10. Dry and wet Granulation
11. Matrix formers
12. Functional Polymer Coatings (IR, easy to swallow, enteric etc.)
13. Amorphous systems (e.g. HME, SD)
14. Micro/Nanoparticles
15. Taste masking polymers
16. Polymers in Orally disintegrating tablets and Orally dissolving films
17. Additive manufacturing (3D printing)
18. Mucoadhesive forms
19. Gastro-retentive forms
20. Polymer blends and additives
1. GI tract environment (e.g. gastric juice, bile salts, pH, amylases, proteases etc.)
2. GI tract motility and transport
3. Drug absorption and pre-systemic metabolism and PK modelling
4. In vitro dissolution and predictive release testing
5. Principle characteristics and specification of pharmaceutical polymers
6. Regulatory Aspects of Polymers Used and new polymers for Oral Medication
Section B. Role Polymer Technology in Oral Drug Delivery
7. Classes/types of polymers used in oral delivery (natural, semi-synthetic, synthetic), their chemical structure and general functionalities
8. Role of polymers in Tableting
9. Capsule forming Polymers
10. Dry and wet Granulation
11. Matrix formers
12. Functional Polymer Coatings (IR, easy to swallow, enteric etc.)
13. Amorphous systems (e.g. HME, SD)
14. Micro/Nanoparticles
15. Taste masking polymers
16. Polymers in Orally disintegrating tablets and Orally dissolving films
17. Additive manufacturing (3D printing)
18. Mucoadhesive forms
19. Gastro-retentive forms
20. Polymer blends and additives
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