Transglutaminase

An introduction to transglutaminases<br>Yi Zhang, Srividya Parthasarathy, and Benjamin K. Simpson<br><br>Chapter 1 Transglutaminases from microorganisms <br>Limin Wang and Yi Wang<br>1. Introduction <br>2. Microbial sources of TGase<br>3. Biotechnological production of MTGase<br>4. Concluding remarks and outlook<br>References<br><br>Chapter 2 Transglutaminases from plant sources<br>Stefano Del Duca and Giampiero Cai<br>1. Introduction<br>2. Phylogenetic relationship and bioinformatic analyses<br>3. Distribution and physiological roles of TGases in plants<br>4. Conclusions <br>References <br><br>Chapter 3 Transglutaminases from animals <br>Jirawat Yongsawatdigul, Ali Hamzeh and Bung-orn Hemung<br>1. Introduction <br>2. Function and distribution<br>3. Conclusions<br>References <br><br>Chapter 4 Newly engineered transglutaminases<br>Han Liu, Ishita Ghosh, Corinne Nardin and Yi Zhang<br>1. Introduction <br>2. Methodology for engineering transglutaminases <br>3. Newly engineered microbial transglutaminases <br>4. Newly engineered animal transglutaminases <br>5. Regulations <br>References <br><br>Chapter 5 Transglutaminase 2 in neurological conditions <br>Thomas Delgado and Gail V.W. Johnson<br>1. Discovery of TG2 and its association with proteinopathies <br>2. TG2&rsquo;s complex role in neuron survival <br>3. TG2 in CNS injury and neuroinflammation <br>4. Epigenetic regulation by TG2 <br>5. Conclusions <br>References <br><br>Chapter 6 Transglutaminases in cardiovascular health and disease <br>Lakshmi Santhanam<br>Abbreviations <br>1. Introduction<br>2. Transglutaminases in the cardiovascular system <br>3. Transglutaminases in vascular diseases <br>4. Transglutaminases in cardiac disease <br>5. Transglutaminases in thromboembolism <br>6. Conclusions and future perspectives <br>References <br><br>Chapter 7 Microbial transglutaminase in drug development <br>Riko Nishioka, Ryo Sato, Kazuki Uchida, Rie Wakabayashi and Noriho Kamiya<br>1. Introduction <br>2. Protein modification using small molecule substrates<br>3. Preparation of proteineprotein conjugates <br>4. Protein modification using synthetic polymeric substrates <br>5. Introduction of hydrophobic molecules into proteins<br>6. Conclusion<br>Acknowledgments<br>References<br><br>Chapter 8 Transglutaminases in meat and seafood bioprocessing <br>Pınar Yerlikaya and Nalan Gokoglu<br>1. Transglutaminases in meat bioprocessing <br>2. Transglutaminases in seafood bioprocessing <br>3. Conclusion <br>References <br><br>Chapter 9 Transglutaminase in dairy processing <br>Ehab Romeih, Marek Kieliszek and Essam Hebishy<br>1. Introduction <br>2. MTGase applications in dairy processing <br>3. Conclusions and future remarks <br>References <br><br>Chapter 10 Transglutaminase in noodles, pastas, and baked products<br>Seyed Mohammad Taghi Gharibzahedi and Zeynep Altintas<br>1. Introduction <br>2. Noodle and TGase <br>3. Pasta and TGase <br>4. Bread and TGase <br>5. Other bakery products and TGase <br>6. Health and nutritional properties<br>7. Conclusions <br>Acknowledgments <br>References <br><br>Chapter 11 Transglutaminase in textile, wool, silk, and leather processing <br>Ning Zhang, Penghui Yang, Man Zhou, Qiang Wang, Song Liu and Jian Chen<br>1. Transglutaminase in wool processing <br>2. Transglutaminase in silk processing <br>3. Transglutaminase in leather processing <br>4. Conclusion <br>References <br><br>Chapter 12 Immobilization of transglutaminases and transglutaminase as immobilization agent <br>Katja Vasic, Zeljko Knez and Maja Leitgeb<br>1. Introduction <br>2. Enzymatic properties of TGase <br>3. Production and substrate preference of TGase <br>4. TGase immobilization <br>5. TGase as immobilizing agent in food and<br>biotechnology industries <br>6. Conclusions<br>Acknowledgments <br>References <br><br>Chapter 13 Industrial production of transglutaminase <br>Keiichi Yokoyama<br>1. Background to food innovation with transglutaminase<br>2. Feasibility study on protein modification by TGase<br>3. Search for a TGase for industrial applications <br>4. Developments for MTGase commercialization <br>5. MTGase in nature <br>6. Recombinant production of MTGase <br>7. MTGase variants with improved properties <br>8. Food safety and regulation <br>9. Concluding remarks <br>References <br>Further reading <br><br>Index