Medicinal Chemistry and Drug Development

1. Medicinal chemistry and process development of the type 2 diabetes drug sitagliptin<br>2. The developmental history of insulin pharmaceuticals<br>3. The developmental trajectory of GLP-1 receptor agonists<br>4. Antidiabetic drugs based on sodium-glucose cotransporter 2 inhibitors<br>5. Cholesterol-lowering drug atorvastatin<br>6. Angiotensin II receptor antagonists for treatment of hypertension: the discovery of losartan and its analogs<br>7. Antithrombotic drug—apixaban<br>8. Development of the anticoagulant drug fondaparinux sodium<br>9. Development of the nucleotide antiviral drug sofosbuvir for the hepatitis C virus<br>10. The first HIV-1 integrase inhibitor, raltegravir<br>11. Discovery and development of the human immunodeficiency virus protease inhibitor Saquinavir<br>12. Baloxavir: an antiinfluenza drug with a novel mechanism of action<br>13. Paclitaxel: a natural antitumor agent<br>14. Antitumor drug eribulin<br>15. Targeted protein kinase inhibitor imatinib<br>16. A case study of the irreversible covalent epidermal growth factor receptor (EGFR) inhibitor—afatinib<br>17. Medicinal chemistry and process development of the antibreast cancer drug tamoxifen<br>18. Triazole antifungal drug—fluconazole<br>19. Discovery of the antibacterial drug Linezolid and its synthetic technology research<br>20. Carbapenem antibiotic meropenem<br>21. Antiparasitic drug praziquantel<br>22. A case study on the proton pump inhibitor omeprazole<br>23. The inhibitors of phosphodiesterase type 5A effectively treat erectile dysfunction<br>24. GABAA receptor agonists: discovery of the general anesthetic propofol and its analogs<br>25. The discovery of risperidone: a case of multiple target antipsychotic drug<br>26. A case study on the first-in-class antirenal anemia drug roxadustat<br>27. Function, pharmaceutical, and pharmacological research and development of natural tetracyclic dipyranocoumarin (1)-calanolide A and its analogs<br>28. Bisphosphonates: a targeted therapeutic medication for skeletal system<br>29. Celecoxib targets cyclooxygenase in nonsteroidal antiinflammatory drugs<br>30. Case study of antisense oligonucleotides for duchenne muscular dystrophy