Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics
Paperback Engels 2024 9780443288746Samenvatting
“Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics provides a comprehensive overview and update of the mass-action law-based unified dose-effect biodynamics, pharmacodynamics, bioinformatics, and the combination index theorem for synergy definition (MAL-BD/PD/BI/CI). Contents advocate the fundamental MAL-PD/BI/CI/BI principle for biomedical R&D, clinical trials protocol design computerized data analysis, illustrates the MAL-dynamics theory with sample analysis, and includes data entry and automated computer report print-outs. In 11 sections “Mass-Action Law Dynamics Theory and Algorithm for Translational and Precision Medicine Informatics leads the reader from an introduction and overview, to trial protocols and MAL-PD/CI approach for biomedical R&D in vitro and in animals. It describes the current Landscape of International FDA Drug Evaluation, Clinical Pharmacology, and Clinical Trials Guidance. This is a valuable resource for biomedical researchers, healthcare professionals, and students seeking to harness the power of data informatics in precision medicine.
Specificaties
Lezersrecensies
Inhoudsopgave
2. General dynamics principle for experimental design of all dose-effect analysis and computer simulation
3. MAL-PD/CI approach for biomedical R&D in vitro and in animals
4. Implementation for MAL-PD Econo-Green R&D
5. Digital R&D approach to international FDA drug evaluation, clinical pharmacology, and clinical trial guidance
6. The epothilone story: Experimental success and clinical failure
7. MAL-PD Advocacy: Public hearing, public comments and scientific recommendations
8. Consensus for international FDAs on definitions of “MAL-PD” and “Synergism”
9. Historical, philosophical, and mathematical analysis: Why the MAL-PD approach and the traditional approach are opposite yet complementary
10. Multidisciplinary examples of applications: Papers using the MAL-PD/BD/CI/BI theory/method
11. Concluding remarks
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