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Transcriptomics in Atherosclerosis

Deciphering Molecular Signatures and Advancing Therapeutic Strategies

Paperback Engels 2025 9780443330643
€ 197,79
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Samenvatting

Transcriptomics in Atherosclerosis: Deciphering Molecular Signatures and Advancing Therapeutic Strategies explores how transcriptomic research is transforming our understanding and management of atherosclerosis. Bridging molecular biology and clinical medicine, it delves into the dynamic regulation of gene expression, the role of non-coding RNAs, and emerging insights from epitranscriptomics.

The book emphasizes advanced technologies such as single-cell and spatial transcriptomics, while embracing systems-level integration with other omic layers. It highlights how these approaches can reveal disease mechanisms, refine risk stratification, and guide the development of RNA-based diagnostics and therapies.

Designed for researchers, clinicians, and translational scientists, this volume moves beyond generic overviews to present current methods, practical insights, and real-world challenges in the field. By doing so, it lays the groundwork for a new generation of precision strategies in cardiovascular care.

Specificaties

ISBN13:9780443330643
Taal:Engels
Bindwijze:Paperback

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Inhoudsopgave

Section I – Introduction<br>1. Atherosclerotic CVD – epidemiology and current challenges in management<br>2. Atherosclerotic Plaque Phenotypes: Unraveling Complexity and Heterogeneity<br><br>Section II – The role of RNAs in atherosclerosis progression and development<br>3. Biogenesis and mechanisms of action of ncRNAs<br>4. The role of ncRNA in plaque development and progression<br>5. Signaling Pathways Regulating Gene Expression in Atherosclerosis<br>6. Epitranscriptomics and Atherosclerosis:<br><br>Section III – Transcriptomic Profiling of Atherosclerotic Lesions<br>7. Essentials of Transcriptomic Methods: Navigating Through RNA Sequencing and Beyond<br>8. Bridging the Gap in Transcriptomics: From Animal to Human Studies in Atherosclerosis<br>9. Translating Transcriptomics into Clinical Practice: Utilizing Gene Expression Patterns for Advanced Patient Phenotyping and Stratification in Atherosclerosis Optimizing Study Design for In-depth Transcriptomic Analysis of Atherosclerotic Plaques<br>10. Unveiling Sex-Specific Transcriptomic Mechanisms in Atherosclerosis<br><br>Section IV – Integrating Multi-Omics Approaches in Atherosclerosis Research<br>11. Combining Transcriptomics with Genomics, Proteomics, and Metabolomics<br>12. Insights into Gene Regulatory Networks in Vascular Pathology<br>13. Systems Biology and Network Analysis<br>14. Use of artificial intelligence and machine learning for multi-omics<br><br>Section V – RNA-Based Theranostics: Revolutionizing Treatment and Diagnosis in Atherosclerotic Cardiovascular Disease<br>15. RNA Therapeutics in Atherosclerosis:<br>16. RNA Therapeutic Delivery Systems – advances and challenges<br>17. Exploring Circulating RNAs: Emerging Biomarkers for Atherosclerosis Detection and Monitoring<br><br>Section VI – Conclusion<br>18. Future Directions and Emerging Technologies in Transcriptomic Research and Atherosclerosis

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€ 197,79
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        Transcriptomics in Atherosclerosis