Structural Studies of Amyloid-Forming Peptides

1. Extraction of Amyloids from Neurodegenerative Disease Tissues for Structural Analysis
2. Cryo-EM Structure Determination of Amyloid Fibrils: Methodology, Insights, and Practical Tools
3. Methods for studying molecular architecture of Ab aggregates in tissues using cryo-ET
4. Cryo-EM methods to study binding between amyloid fibrils and chemical compounds or ligan
5. Dynamics studies of side-chains and hydration shells in amyloid-beta fibrils using deuterium and oxygen-17 solid-state NMR
6. Technical aspects of pressure jump NMR applied to the study of Abeta and protein oligomerization
7. Characterizations of the beta-amyloid-membrane interaction intermediates
8. Time-resolved solid-state NMR studies of oligomer formation.
9. Methods for characterizing the individual filament structures of amyloid peptide assemblies using atomic force microscopy
10. Single-molecule fluorescence spectroscopy and imaging on heterogeneous amyloid beta aggregation
11. Two-dimensional FT-IR methods on amyloid aggregation and folding pathways
12. Application of EPR spectroscopy in the structural studies of Aβ oligomers and fibrils
13. Identification of amyloid polymorphisms in brain tissues based on conformational-sensitive dyes
14. Molecular simulation methods for amyloid-membrane interactions
15. How to prepare Alzheimer's amyloid-beta oligomer samples with sufficient quantity and quality for solid-state NMR measurements