Human Prion Diseases
Gebonden Engels 2018 9780444639455Levertijd ongeveer 9 werkdagen
Gratis verzonden
Samenvatting
Human Prion Diseases, Volume 153 is designed to update the reader on the latest advances and clinical aspects of prion diseases. The book is organized into five sections, including the pathophysiology of prions and a description of animal and human diseases. This is followed by detailed reports on recent advances in diagnosis strategies for the development of novel anti-prion molecules and possible designs of clinical trials in such a rare disease. An introductory chapter gives an extensive historical background of prion research, with a final chapter highlighting recent progress, and more importantly, unsolved problems.
Specificaties
Lezersrecensies
Wees de eerste die een lezersrecensie schrijft!
Inhoudsopgave
1. Historical view
Section I: Pathophysiology of prions
2. The cellular and pathological prion protein
3. Cell biology of prion infection
4. Experimental models of human prion diseases and prion strains
5. The role of the immune system in prion infection
Section II: Animal prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes)
6. Typical and atypical scrapie
7. Typical and atypical BSE
8. Chronic Wasting Disease
Section III: Human prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes)
9. Sporadic Creutzfeldt-Jakob Disease
10. Variably protease-sensitive prionopathy
11. Variant Creutzfeldt-Jakob Disease
12. Iatrogenic Creutzfeldt-Jakob Disease
13. Genetic Creutzfeldt-Jakob Disease
14. Gerstmann-Sträussler-Scheinker disease
15. Sporadic and fatal Familial Insomnia
Section IV: Prion-like mechanisms in other neurodegenerative diseases
16. Prion-like mechanisms in Alzheimer
17. Prion-like mechanisms in Parkinson
18. Prion-like mechanisms in ALS
Section V: Diagnosis and treatment
19. Prion protein amplification techniques
20. Differential diagnosis with other rapid progressive dementias
21. Symptomatic treatment, care and support of CJD patients
22. Identifying therapeutic targets and treatment in model systems
23. Vaccination strategies
24. Clinical trials
Section VI: Public health issues
25. Animal diseases and the zoonotic potential
26. Safety of blood, blood derivatives and plasma-derived products
27. Safety in clinical practice
28. Concluding thoughts
Section I: Pathophysiology of prions
2. The cellular and pathological prion protein
3. Cell biology of prion infection
4. Experimental models of human prion diseases and prion strains
5. The role of the immune system in prion infection
Section II: Animal prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes)
6. Typical and atypical scrapie
7. Typical and atypical BSE
8. Chronic Wasting Disease
Section III: Human prion diseases (clinical, epidemiology, neuropathological, biochemical, biomarker, and genotypes)
9. Sporadic Creutzfeldt-Jakob Disease
10. Variably protease-sensitive prionopathy
11. Variant Creutzfeldt-Jakob Disease
12. Iatrogenic Creutzfeldt-Jakob Disease
13. Genetic Creutzfeldt-Jakob Disease
14. Gerstmann-Sträussler-Scheinker disease
15. Sporadic and fatal Familial Insomnia
Section IV: Prion-like mechanisms in other neurodegenerative diseases
16. Prion-like mechanisms in Alzheimer
17. Prion-like mechanisms in Parkinson
18. Prion-like mechanisms in ALS
Section V: Diagnosis and treatment
19. Prion protein amplification techniques
20. Differential diagnosis with other rapid progressive dementias
21. Symptomatic treatment, care and support of CJD patients
22. Identifying therapeutic targets and treatment in model systems
23. Vaccination strategies
24. Clinical trials
Section VI: Public health issues
25. Animal diseases and the zoonotic potential
26. Safety of blood, blood derivatives and plasma-derived products
27. Safety in clinical practice
28. Concluding thoughts
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