Idiotypes in Medicine: Autoimmunity, Infection and Cancer

List of Contributors.<br><p> <br>General Section <br><br>Anti-idiotypes as Vaccines: Theoretical Considerations <br> ( A. Nisonoff)<br><br>Anti-idiotypes ( C.A. Bona)<br><br>X-ray Crystallographic Studies of the Idiotypic Cascade (N. Ban and A. McPherson)<br><br>The Structure and Thermodynamics of Antibody-Protein Antigen Interactions (B.C. Braden and R.J. Poljak)<br><p> <br>Autoimmunity Section<br> <br>Introduction - Idiotypes and Anti-idiotypes (M. Abu-Shakra, D. Buskila and Y. Shoenfeld)<br><br>Cross-Reactive Idiotypes in Human Lupus Families (P. Youinou)<br><br>Idiotypes of Anti-DNA Antibodies (D. Buskila, M. Abu-Shakra and Y. Shoenfeld)<br><br>Idiotypes of Anti-Sm Antibodies (H. Dang and N. Talal)<br><br>Idiotypes of anti-Ro and anti-La (Y.B. Dayan, H. Amital and Y. Shoenfeld)<br><br>Idiotypes on autoantibodies in myasthenia gravis (A.K. Lefvert)<br><br>Idiotypes of ANCA (E. Csernok and W.L. Gross)<br><br>Ig Genes and Idiotype of Anti-Mitochondrial Antibodies in Primary Biliary Cirrhosis (P.S.C. Leung and M.E. Gershwin)<br><br>Idiotypes of anti-Phospholipid Antibodies (R. Bakimer and Y. Shoenfeld)<br><br>Anti-Idiotypic antibodies Against Human Insulin autoantibodies (IAA) (S. Kyurkchiev, M. Stamenova, V. Manolova, V. Tsvetkova, L. Dakovska and I. Kehayov)<br><br>Molecular and cellular aspects of human rheumatoid factor production and idiotypes (R.A. Mageed, S.P. Moyes, K.M. Thompson and J.B. Natvig)<br> <br>Idiotypes of anti-Thyroglobulin Antibodies (Y. Tomer)<br><br>Idiotypes of Human Platelet-Specific Antibodies (T.J. Kunicki and D.J. Nugent)<br><br>Idiotypes of platelet associated antibodies (Autoimmune thrombocytopenia) (M. Abu-Shakra, D. Buskila and Y. Shoenfeld)<br><br>Idiotypes of Natural Autoantobodies and Monoclonal Gammopathies (M. Abu-Shakra, D. Buskila and Y. Shoenfeld)<br><br>Idiotypes and anti-idiotypes in Allergy (M.G. Jacquemin and J.-M.R. Saint-Remy)<br><br>Anti-idiotypes to Autoantibodies in Therapeutic Preparations of Normal Polyspecific Human IgG <br>(Intravenous Immunoglobulin, IVIg) (S.H. Spalter, S. Kaveri and M.D. Kazatchkine)<br><br>Manipulation of Autoantibody Idiotypes In Autoimmune Diseases (D. Buskila, M. Abu-Shakra and Y. Shoenfeld)<br><br>Anti-Idiotypic Monoclonal Antibody (mAb) to Anti-CD4 mAb as Surrogate of Human CD4 Antigen (Ag) for Active Immunotherapy of Autoimmune Diseases (F. Perosa, M. Scudeletti, F. Indiveri and F. Dammacco)<br><p><br>Infection Section<br> <br>Introduction (R.C. Kennedy)<br><br>Anti-Idiotypic Studies of the Glycoprotine B (gB, UL55) Complex of Human Cytomegalovirus: Mimicry of a Neutralizing Epitope and Development of Diagnostics (E.S. Tackaberry, J. Hamel and B.R. Brodeur)<br><br>Anti-Idiotype Antibody in HIV-1-Infected Thrombocytopenic Patients (S. Karpatkin and M.A. Nardi)<br><br>An Electron Microscopic View of the Geometry and Dynamics of Idiotype-Anti-Idiotype Interactions (K.H. Roux and N.S. Greenspan)<br><br>Probing Human Antibody Diversity in HIV Infection (S. Karray and M. Zouali)<br><br>Anti-idiotype mimics of Pseudomonas aeruginosa surface polysaccharides (J.R. Schreiber)<br><br>Modulation of the immune response to simian virus 40 large tumor antigen via idiotype-anti-idiotype interactions (M.H. Shearer, H.I. Pass, M. Carbone and R.C. Kennedy) <br><br>The perpetual network theory and its putative applications: 21 years later (H.C.J. Ertl)<br><br>An Anti-Idiotypic Antibody as a Functional Mirror Image of a Viral Antigen (Y. Thanavala)<br><br>Anti-Idiotype to Bluetongue Virus VP7 Antigen: Potential Diagnostic Reagent and Vaccine (E.-M. Zhou and M. Lin)<br><br>An Idiotype Vaccine Against Gram-Negative Bacterial Sepsis (R.E. Ward)<br><br>Yeast Killer Toxin-Like Antibodies in Experimental and Clinical Candidasis (L. Polonelli, F. De Bernardis, S. Conti, M. Gerloni and A. Cassone)<br><br>Anti-Idiotypic Antibodies and Idiotypic T Cell Selection in HIV Infection: <br><br>1. Idiotypes on HIV Specific Antibodies as Disease Markers in AIDS and their Potential as Immunotherapeutic Agents. <br><br>2. T Cell Repertoire and Idiotypes in HIV Infection (S. M&uuml;ller and M. Grant)<br><br>Probing Human Polysaccharide-Specific Antibody Repertoires using Anti-Idiotypes (A.H. Lucas)<br><br>Anti-Idiotypic Antibodies in HIV-Infected Patients to a Neutralizing Mab and its Complementarity Determining Regions (M. Levi, J. Hinkula and B. Wahren)<br><br>Epstein-Barr Virus-Induced Autoimmunity Through Anti-Idiotype Studies (C. Garzelli, M. Incaprera, A. Bazzichi and G. Falcone)<br> <p><br>Cancer Section<br> <br>Introduction (S. Ferrone)<br><br>Cancer Therapy with Anti-Idiotypic Antibodies (O. Merimsky, P. Fishman and Y. Shoenfeld)<br><br>Immunotherapy of Cancer Patients with Anti-Idiotype Vaccines (M. Bhattacharya-Chatterjee, H. K&ouml;hler and K.A. Foon)<br><br>Anti-Idiotype Antibodies Mimicking Carcinoembryonic Antigen (M. Monestier)<br><br>Immunological and Molecular Characterization of an Idiotypic Cascade Specific for the Human Carcinoembryonic Antigen (M. Neumaier, F.-J. Gaida, D. Pieper, M.A. Sherman and J.E. Shively)<br><br>Anti-Idiotypic Antibodies that Mimic the Colorectal Cancer Antigen CO17-1A/GA733: Twelve Years of Pre-Clinical and Clinical Studies (D. Herlyn, R. Somasundaram, L. Jacob, W. Li, J. Zaloudik, H. Maruyama, A. Benden, D. Harris and M. Mastrangelo)<br><br>Idiotypic Network Responses and Anti-Idiotypes in Cancer Therapy (J. Fagerberg, P. Ragnhammar and H. Mellstedt)<br><br>Anti-Idiotypes in Ovarian Cancer (U. Wagner, H. Schlebusch, J. Schmolling, J. Reinsberg and D. Krebs)<br><br>Anti-Idiotype Antibodies in Renal Cell Carcinoma (H. Uemura and E. Oosterwijk)<br><br>Clinical Studies with Anti-Idiotypic Monoclonal Antibody BEC2 that Mimics GD3 Ganglioside (P.B. Chapman)<br><br>The Anti-Idiotypic Approach to Active Specific Immunotherapy of Malignant Melanoma ( X. Wang, S. Desai, E.J. Noronha, A. Mittelman and S. Ferrone)<br><br>Subject Index