In Vitro Methods in Toxicology

Introduction G. B. Leslie and P. Johnson; Part I. Target Organ Toxicity: 1. In vitro methods in renal toxicology M. A. Snith, W. R. Hewitt and J. Hook; 2. Ototoxicity E. S. Harpur; 3. Cultured cell models for studying problems in cardiac toxicology N. Sperelakis and G. Bkaily; 4. Use of the isolated rat heart for the detection of cardiotoxic agents A. Cockburn; 5. Brain reaggregate cultures in neurotoxicological investigations C. K. Atterwill; 6. Application of thyroid cell culture to the study of thyrotoxicity C. G. Brown; 7. In vitro methods to investigate toxic lung disease A. Poole and R. C. Brown; 8. Metabolism and toxicity of drugs in mammalian hepatocyte culture R. J. Chenery; 9. In vitro evaluation of haemic systems in toxicology J. S. H. Luke and G. R. Betton; Part II. General and Topical Toxicity: 10. The chorioallantoic membrance in irritancy testing R. S. Lawrence; 11. In vitro dermal irritancy tests P. A. Duffy and O. P. Flint; 12. Genetic toxicology M. Richold; 13. In vitro immunotoxicology K. Miller, S. Nicklin and S. G. Volsen; Part III. Reproductive Toxicity: 14. An in vitro test for teratogens using cultures of rat embryo cells O. P. Flint; 15. Postimplantion embryo culture and its application to problems in teratology D. L. Cockroft and C. E. Steele; 16. Sub-mammalian and sub-vertebrate models in teratogenicity screening S. J. Freeman and N. A. Brown; 17. The use of in vitro techniques to investigate the action of testicular toxicants D. A. Garside; 18. An in vitro assessment of ovarian function: a potential tool for investigating mechanisms of toxicity in the ovary D. A. Garside and P. McKibbin; Part IV. Conclusion: 19. Conclusion C. K. Atterwill and C. E. Steele; Index.