Edward C. Stites,
Edward C. (Salk Inst itute for Biological Studies, La Jolla, CA) Stites,
Kendra Paskvan,
Kendra (Pacific Northwes t University for Health Sciences, Yakima, WA) Paskvan,
Shumei Kato,
Shumei (University of California, San Diego Moores Cancer Center) Kato
e.a.
Therapeutic Targeting of RAS Mutant Cancers
Paperback Engels 2022 9781009073646Levertijd ongeveer 9 werkdagen
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Samenvatting
The KRAS oncogene is believed to be the most common single nucleotide variant oncogene in human cancer. Historically, efforts to target KRAS and the other RAS GTPases have struggled. More recently, efforts have focused on identifying and exploiting features unique to specific oncogenic mutations. This has led to the first FDA approval for a RAS targeted therapy. This new agent is a covalent inhibitor that reacts with the cysteine residue created by a codon 12 glycine to cysteine (G12C) mutation within KRAS. Mutant-specific strategies may also exist for other KRAS single nucleotide variants, and recent studies provide examples and mechanisms.
Specificaties
ISBN13:9781009073646
Taal:Engels
Bindwijze:Paperback
Aantal pagina's:75
Uitgever:Cambridge University Press
Serie:Elements in Molecula
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Inhoudsopgave
Introduction; RAS Biology; Oncogenic RAS; RAS Targeting; Downstream Targeting; Upstream Targeting; Targeting Specific RAS Mutants; KRAS G12C Targeting; Direct Targeting of Other RAS Proteins; KRAS G12R Pancreatic Cancer; KRAS G13D Colorectal Cancer; Summary; References.
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