Ribozymes

<p>Conjugation as a Highly Sensitive Assay to Study Group II Intron Splicing in vivo.-&nbsp;Co-transcriptional Analysis of Self-cleaving Ribozymes and their Ligand Dependence.-&nbsp;Cloning and Detection of Genomic Retrozymes and their circRNA Intermediates.-&nbsp;Demonstration of a Ribozyme in Epsilon Domain of Hepatitis B Virus RNA.-&nbsp;In vitro Selection of Varkud Satellite Ribozyme Variants that Cleave a Modified Stem-loop Substrate.-&nbsp;Characterization and Optimization of a Deoxyribozyme with a Short Left Binding Arm.-&nbsp;Computer-aided Design of Active Pseudoknotted Hammerhead Ribozymes.-&nbsp;Inverse RNA Folding Workflow to Design and Test Ribozymes Including Pseudoknots.-&nbsp;Using an L7Ae-tethered, Hydroxyl Radical-Mediated Footprinting Strategy to Identify and Validate Kink-Turns in RNAs.-&nbsp;SHAPE Profiling to Probe Group II Intron Conformational Dynamics during Splicing.-&nbsp;Dynamics-Function Analysis in Catalytic RNA Using NMR Spin Relaxation and Conformationally Restricted Nucleotides.-&nbsp;Design and Evaluation of Guide RNA Transcripts with a 3’-terminal HDV Ribozyme to Enhance CRISPR-based Gene Inactivation.-&nbsp;Design and Evaluation of AgoshRNAs with 3’-terminal HDV Ribozymes to Enhance the Silencing Activity.-&nbsp;Cloning and Detection of Aptamer-ribozyme Conjugations.-&nbsp;Use of a Lariat Capping Ribozyme to Study Cap Function in Vivo.-&nbsp;Long Non-coding RNA Depletion using Self-cleaving Ribozymes.&nbsp;</p>

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