Mitochondrial Medicine

Using QSAR Models to Predict Mitochondrial Targeting by Small Molecule Xenobiotics within Living Cells.-&nbsp;DQAsomes as the Prototype of Mitochondria-targeted Pharmaceutical Nanocarriers: An Update.-&nbsp;Synthesis and Characterization of Mitochondria-Targeted Triphenyltriphenylphosphonium Bolaamphiphiles.-&nbsp;Synthesis and Evaluation of ¹⁸F-labeled Fluoroalkyl Triphenylphosphonium Salts as Mitochondrial Voltage Sensors in PET Myocardial Imaging.-&nbsp;Novel Mitochondria-Targeted Triphenylphosphonium Conjugates of Linear beta-Phosphorylated Nitrones: Preparation, ³¹P NMR Mitochondrial Distribution, EPR Spin Trapping Reporting, and Site-Directed Anti-Apoptotic Properties.-&nbsp;Insights on Targeting Small Molecules to the Mitochondrial Matrix and the Preparation of MitoB and MitoP as exomarkers of Mitochondrial Hydrogen Peroxide.-&nbsp;Synthesis of Triphenylphosphonium Phospholipid Conjugates for the Preparation of Mitochondriotropic Liposomes.-&nbsp;Imaging Mitochondrial Hydrogen Peroxide in Living Cells.-&nbsp;Synthesis and Testing Of Novel Isomeric Mitochondriotropic Derivatives of Resveratrol and Quercetin.-&nbsp;Bridging the Gap between Nature and Antioxidant Setbacks: Delivering Gallic Acid to Mitochondria.-&nbsp;Liposomal Delivery of Cyclocreatine Impairs Cancer Cell Bioenergetics Mediating Apoptosis.-&nbsp;Mt-fura-2, a ratiometric Mitochondria-targeted Ca²⁺ sensor. Determination of spectroscopic properties and Ca²⁺ Imaging Assays.-&nbsp;Sequence-Specific Control of Mitochondrial Gene Transcription using Programmable Synthetic Gene Switches called MITO-PIPs.-&nbsp;Targeting the Mitochondrial Genome via a MITO-Porter: Evaluation of mtDNA and mtRNA Levels and Mitochondrial Function.-&nbsp;mTRIP, an Imaging Tool to Investigate Mitochondrial DNA dynamics in Physiology and Disease at the Single-Cell Resolution.-&nbsp;Development of Mitochondria-Targeted Imaging Nanoplatforms by Incorporation of Fluorescent Carbon Quantum Dots.-&nbsp;Norbormide-based Probes and their Application for Mitochondrial Imaging in Drosophila Melanogaster.-&nbsp;Live-cell Assessment of Reactive Oxygen Species Levels Using Dihydroethidine.-&nbsp;Protein Supercomplex Recording In Living Cells Via Position-Specific Fluorescence Lifetime Sensors.-&nbsp;Identification of Peroxynitrite by Profiling Oxidation and Nitration Products from Mitochondria-Targeted Arylboronic Acid.-&nbsp;Mitochondrial Coenzyme Q10 Determination via Isotope Dilution Liquid Chromatography Tandem Mass Spectrometry.-&nbsp;Janus-type Mesoporous Silica Nanoparticles for Sequential Tumoral Cell and Mitochondria Targeting.-&nbsp;Split Green Fluorescent Protein-Based Contact Site Sensor (SPLICS) for Heterotypic Organelle Juxtaposition as Applied to ER – Mitochondria Proximities.-&nbsp;Qualitative Characterization of the Rat liver Mitochondrial Lipidome using All Ion Fragmentation on an Exactive Benchtop Orbitrap MS.-&nbsp;Live Imaging of Mitochondria in Kidney Tissue.-&nbsp;Time-resolved Imaging of Mitochondrial Flavin Fluorescence and Its Applications for Evaluating the Oxidative State in Living Cardiac Cells.-&nbsp;Mito-SinCe²Approach to Analyze Mitochondrial Structure-Function In Single Cells.-&nbsp;Computer-aided Prediction of Protein Mitochondrial Localization.<p><br></p>