Mapping Genetic Interactions

Quantitative Genetic Screens for Mapping Bacterial Pathways and Functional Networks.-&nbsp;Mapping Synthetic Dosage Lethal Genetic Interactions&nbsp;in&nbsp;Saccharomyces cerevisiae.-&nbsp;Systematic High-Content Screening of Fluorescently-Tagged Yeast Double Mutant Strains.-&nbsp;A Genetic Interaction Screening Approach in C. elegans.-&nbsp;RNA Interference (RNAi) Screening in Cultured Drosophila Cells.- Employing Cross-Species Approaches to Construct Humanized Genetic Interaction Networks.- Identification of Synthetic Lethal Interactions Using High-Throughput, Arrayed CRISPR/Cas9-based Platforms.-&nbsp;Exploring Candidate Human Synthetic Lethal Interactions Through siRNA and Quantitative Imaging-Based Approaches.-&nbsp;Mapping Genetic Interactions in Human Cancer&nbsp;Cells&nbsp;Using a One-Step&nbsp;tRNA-CRISPR&nbsp;System.-&nbsp;In vivo Genome-Wide Pooled RNAi Screens in Cancer Cells to Identify Determinants of Chemotherapy/Drug Response.- INCISOR: An Algorithm to Identify Synthetic Rescue Mediators of Resistance to Targeted and Immunotherapy.-&nbsp;Machine Learning to Identify Gene Interactions from High-Throughput Mutant Crosses.-&nbsp;Identification of Drug Resistance Genes Using a Pooled Lentiviral CRISPR/Cas9 Screening Approach.-&nbsp;Chemical&nbsp;Genetic Interactions&nbsp;as a Means to Characterize Drug Synergy.-&nbsp;Puromycin Labeling Coupled with Proximity Ligation Assays to Define Sites of mRNA Translation in Drosophila Embryos and Human Cells.-&nbsp;Inferring Copy Number from Triple Negative Breast Cancer Patient Derived Xenograft scRNAseq Data using scCNAutils.-&nbsp;Generation of Protein Inhibitors for Validation of Cancer Drug Targets Identified in Functional Genomic Screens.- Computational Prediction of Chemical Tools for Identification and Validation of Synthetic Lethal Interaction Networks.<p><br></p>