Chemogenomics

<div>&nbsp;An Introduction to Chemogenomics.-&nbsp;Developing a Kinase Chemogenomic Set: Facilitating Investigation into Kinase Biology by Linking Phenotypes to Targets.-&nbsp;Compilation of Custom Compound/Bioactivity Datasets from Public Repositories.-&nbsp;Quality Control of Chemogenomic Library using LC-MS.-&nbsp;Annotation of the Effect of Chemogenomic Compounds on Cell Health using High-Content Microscopy in Live-Cell Mode.-&nbsp;Characterization of Cellular Viability using Label-Free Brightfield Live-Cell Imaging.-&nbsp;Plate-Based Screening for DUB Inhibitors.-&nbsp;NanoBRET™ Live Cell Kinase Selectivity Profiling Adapted for High Throughput Screening.-&nbsp;A Fluorescence-Based Reporter Gene Assay to Characterize Nuclear Receptor Modulators.-&nbsp;Measuring Protein-Protein Interactions in Cells using NanoLuciferase Bioluminescence Resonance Energy Transfer (NanoBRET) Assay.-&nbsp;HiBiT Cellular Thermal Shift Assay (HiBiT CETSA).-&nbsp;Detection of Cellular Target Engagement for Small Molecule Modulators of Striatal-Enriched Protein Tyrosine Phosphatase (STEP).-&nbsp;Target Deconvolution by Limited Proteolysis Coupled to Mass Spectrometry.-&nbsp;Global Assessment of Drug Target Engagement and Selectivity of Covalent Cysteine-Reactive Inhibitors using Alkyne-Functionalized Probes.-&nbsp;3D-Spheroid Invasion Assay for High-Throughput Screening of Small Molecule Libraries.-&nbsp;Live-Cell High-Throughput Screen for Monitoring Autophagy Flux.-&nbsp;Phenotypic Chemical Screening in CD4+ T Cells to Identify Epigenetic Inhibitors.</div><br><div><br></div><div><br></div><div><br></div>