RNA Nanostructures

Molecular Dynamics Simulations of RNA Motifs to Guide the Architectural Parameters and Design Principles of RNA Nanostructures.-&nbsp;Computer assisted design and characterization or RNA nanostructures.- Combining Experimental Restraints and RNA 3D Structure Prediction in RNA Nanotechnology.- Structural Characterization of Nucleic Acid Nanoparticles using SAXS and SAXS-driven MD.- Metalated Nucleic Acid Nanostructures.-&nbsp;Bioconjugation of Functionalized Oligodeoxynucleotides with Fluorescence Reporters for Nanoparticle Assembly.-&nbsp;Light-assisted drying for the thermal stabilization of nucleic acid nanoparticles and other biologics.-&nbsp;Preparation of Nucleic Acid Aptamer Functionalized Silver/Gold Nanoparticle Conjugates.-&nbsp;Thermodynamic Characterization of Nucleic Acid Nanoparticles Hybridization by UV Melting.-&nbsp;Structural Characterization of DNA Templated Silver Nanoclusters by Energy Dispersive Spectroscopy.-&nbsp;Small Volume microrheology to Evaluate Viscoelastic Properties of Nucleic Acid-based Hydrogels.-&nbsp;Characterization of RNA Nanoparticles and Their Dynamic Properties Using Atomic Force Microscopy.-&nbsp;Synthesis of Mesoporous Silica Nanoparticles for the Delivery of Nucleic Acid Nanostructures.-&nbsp;Assessment of intracellular compartmentalization of RNA nanostructures.-&nbsp;Discriminating immunorecognition pathways activated by RNA nanostructures.- Detection of nanoparticles' ability to stimulate toll-like receptors using HEK-Blue reporter cell lines.- Complexing PAMAM Dendrimers to Nucleic Acid Nanoparticles for their Intracellular Delivery.-&nbsp;Reverse transfection of functional RNA rings into cancer cells followed by in vitro irradiation.-&nbsp;RNA/DNA nanostructures designed for efficient regulation of blood coagulation.- Detection of multiplex NASBA RNA products using colorimetric split G quadruplex probes.- Synthesis of DNA-Templated Silver Nanoclusters and the Characterization of Their Optical Properties and Biological Activity.- Dynamic nanostructures for conditional activation and deactivation of biological pathways.-&nbsp;Anticoagulant activity of nucleic acid nanoparticles assessed by thrombin generation dynamics on a fully-automated system.&nbsp;<p><br></p>