Zbigniew J. (Wilkes University, PA) Witczak,
ZJ Witczak,
Roman (Wilkes University, PA) Bielski
Click Chemistry in Glycoscience – New Developments and Strategies
New Developments and Strategies
Gebonden Engels 2013 9781118275337
Verwachte levertijd ongeveer 9 werkdagen
Samenvatting
The first text to focus on the application of click chemistry to glycoscience, this book discusses the therapeutic and pharmacological aspects of carbohydrate click chemistry and includes chapters on the concept′s background, as well as its industrial applications in areas such as drug discovery. The book reflects the novel methodologies and strategies of this concept. Each chapter describes new approaches, ideas, consequences, and applications deriving from the introduction of click processes. This provides an essential reference for a wide range of researchers and graduate–level students.
Specificaties
Lezersrecensies
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Inhoudsopgave
<p>FOREWORD vii</p>
<p>PREFACE ix</p>
<p>CONTRIBUTORS xiii</p>
<p>LIST OF ABBREVIATIONS xvii</p>
<p>I CLICK CHEMISTRY STRATEGIES AND DECOUPLING</p>
<p>1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling 3<br /> Roman Bielski and Zbigniew J. Witczak</p>
<p>II THIO–CLICK CHEMISTRY OF CARBOHYDRATES</p>
<p>2 Thio–Click Chemistry in Glycoscience: Overview and Perspectives 33<br /> Zbigniew J. Witczak</p>
<p>3 Free–Radical Thiol–ene and Thiol–yne Couplings as Click Processes for Glycoconjugation 45<br /> Alessandro Dondoni and Alberto Marra</p>
<p>III CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS</p>
<p>4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions 79<br /> Michael D. Best</p>
<p>5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds 107<br /> Maria Laura Uhrig and Jos´e Kovensky</p>
<p>6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces 143<br /> Carmen Ortiz Mellet, Alejandro M´endez–Ardoy, and Jos´e Manuel Garc´©¥a Fern´andez</p>
<p>7 Toward Imaging Glycotools by Click Coupling 183<br /> Yves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine Lamand´e–Langle</p>
<p>8 Bioorthogonal Reactions for Labeling Glycoconjugates 211<br /> Fr´ed´eric Friscourt and Geert–Jan Boons</p>
<p>9 Sweet Sucrose Macrocycles via a Click Chemistry Route 235<br /> Mykhaylo A. Potopnyk and S©©awomir Jarosz</p>
<p>IV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES</p>
<p>10 Neoglycoprotein Synthesis Using the Copper–Catalyzed Azide Alkyne Click Reaction and Native Chemical Ligation 253<br /> Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent, and Margaret A. Brimble</p>
<p>11 Biomedical Applications of Click –Modified Cyclodextrins 271<br /> Zhenshan Jia, Rakesh K. Singh, and Dong Wang</p>
<p>12 Triazolyl Glycoconjugates in Medicinal Chemistry 293<br /> Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha, and Vinod Kumar Tiwari</p>
<p>13 Click Chemistry Applied to Carbohydrate–Based Drug Discovery 325<br /> Vanessa Leiria Campo and Ivone Carvalho</p>
<p>INDEX 359</p>
<p>PREFACE ix</p>
<p>CONTRIBUTORS xiii</p>
<p>LIST OF ABBREVIATIONS xvii</p>
<p>I CLICK CHEMISTRY STRATEGIES AND DECOUPLING</p>
<p>1 Paradigm and Advantage of Carbohydrate Click Chemistry Strategy for Future Decoupling 3<br /> Roman Bielski and Zbigniew J. Witczak</p>
<p>II THIO–CLICK CHEMISTRY OF CARBOHYDRATES</p>
<p>2 Thio–Click Chemistry in Glycoscience: Overview and Perspectives 33<br /> Zbigniew J. Witczak</p>
<p>3 Free–Radical Thiol–ene and Thiol–yne Couplings as Click Processes for Glycoconjugation 45<br /> Alessandro Dondoni and Alberto Marra</p>
<p>III CARBOHYDRATE CLICK CHEMISTRY FOR NOVEL SYNTHETIC TARGETS</p>
<p>4 The Development and Application of Clickable Lipid Analogs for Elucidating and Harnessing Lipid Functions 79<br /> Michael D. Best</p>
<p>5 Clicking Sugars onto Sugars: Oligosaccharide Analogs and Glycoclusters on Carbohydrate Scaffolds 107<br /> Maria Laura Uhrig and Jos´e Kovensky</p>
<p>6 Click Multivalent Glycomaterials: Glycoclusters, Glycodendrimers, Glycopolymers, Hybrid Glycomaterials, and Glycosurfaces 143<br /> Carmen Ortiz Mellet, Alejandro M´endez–Ardoy, and Jos´e Manuel Garc´©¥a Fern´andez</p>
<p>7 Toward Imaging Glycotools by Click Coupling 183<br /> Yves Chapleur, Christine Vala, Franc¸oise Chr´etien, and Sandrine Lamand´e–Langle</p>
<p>8 Bioorthogonal Reactions for Labeling Glycoconjugates 211<br /> Fr´ed´eric Friscourt and Geert–Jan Boons</p>
<p>9 Sweet Sucrose Macrocycles via a Click Chemistry Route 235<br /> Mykhaylo A. Potopnyk and S©©awomir Jarosz</p>
<p>IV CARBOHYDRATE CLICK CHEMISTRY IN BIOMEDICAL SCIENCES</p>
<p>10 Neoglycoprotein Synthesis Using the Copper–Catalyzed Azide Alkyne Click Reaction and Native Chemical Ligation 253<br /> Joanna M. Wojnar, Dong Jun Lee, Clive W. Evans, Kalyaneswar Mandal, Stephen B. H. Kent, and Margaret A. Brimble</p>
<p>11 Biomedical Applications of Click –Modified Cyclodextrins 271<br /> Zhenshan Jia, Rakesh K. Singh, and Dong Wang</p>
<p>12 Triazolyl Glycoconjugates in Medicinal Chemistry 293<br /> Rama Pati Tripathi, Pratibha Dwivedi, Anindra Sharma, Divya Kushwaha, and Vinod Kumar Tiwari</p>
<p>13 Click Chemistry Applied to Carbohydrate–Based Drug Discovery 325<br /> Vanessa Leiria Campo and Ivone Carvalho</p>
<p>INDEX 359</p>
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