Osteoporosis

Preface. Authors. Contributors. The burden of osteoporosis. DOHaD: The concept, its implications and applications. Early growth, bone development and risk of adult fracture. Maternal nutrition, lifestyle and anthropometry during pregnancy, and offspring bone development. Vitamin D in early life: From observation to intervention. Nutrition and bone health during childhood and adolescence: A global perspective. Developmental plasticity, epigenetic mechanisms and early life influences on adult health and disease: Fundamental concepts. Epigenetic mechanisms in bone development. The material and structural basis of the growth-related gain and age-related loss of bone strength. Risk factors for post peak bone mass bone loss and osteoporotic fracture: Lessons from population studies. Risk factors for post peak bone loss and osteoporotic fracture: Lessons from novel imaging studies. Assessment of fracture risk. Therapeutic approaches to bone protection in adulthood. A lifecourse perspective on bone health and disease: Scientific and social implications. Epilogue. Index.